| Identification | More | [Name]
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride | [CAS]
2328-12-3 | [Synonyms]
1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-ISOQUINOLINE HYDROCHLORIDE
6,7-DIMETHOXY-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
ISOQUINOLINE, 1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-, HYDROCHLORIDE
LABOTEST-BB LT00453025
TIMTEC-BB SBB003285
1,2,3,4-tetrahydro-6,7-dimethoxy-isoquinolinhydrochloride
6,7-Dimethoxy-1,2,3,4-tetrahyroisoquinoline hydrochloride, 97%
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinolineHCl
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride 97%
1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-ISOQUINOLEINE HYDROCHLORIDE 97+% | [EINECS(EC#)]
251-223-7 | [Molecular Formula]
C11H16ClNO2 | [MDL Number]
MFCD00012744 | [Molecular Weight]
229.7 | [MOL File]
2328-12-3.mol |
| Chemical Properties | Back Directory | [Appearance]
white to slightly beige shiny flakes or | [Melting point ]
260-265 °C(lit.) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
soluble25mg/mL, clear, colorless (1N NaOH in methanol) | [form ]
Shiny Flakes or Crystalline Powder | [color ]
White to slightly beige | [Water Solubility ]
soluble 25mg/mL, clear, colorless (1N NaOH in methanol) | [BRN ]
3634126 | [InChI]
InChI=1S/C11H15NO2.ClH/c1-13-10-5-8-3-4-12-7-9(8)6-11(10)14-2;/h5-6,12H,3-4,7H2,1-2H3;1H | [InChIKey]
SHOWAGCIRTUYNA-UHFFFAOYSA-N | [SMILES]
C12CCNCC=1C=C(OC)C(OC)=C2.Cl | [CAS DataBase Reference]
2328-12-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [RTECS ]
NX5017980
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29334900 | [Toxicity]
mouse,LD50,intraperitoneal,272mg/kg (272mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Yakugaku Zasshi. Journal of Pharmacy. Vol. 88, Pg. 1197, 1968. |
| Hazard Information | Back Directory | [Chemical Properties]
white to slightly beige shiny flakes or | [Uses]
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride has been used as starting material for the synthesis of more complex isoquinolines and quinolizidines. | [Definition]
ChEBI: 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is a member of isoquinolines. | [General Description]
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride is also referred as heliamine. It is an alkaloid isolated from mexican cereoid, Backebergia militaris. | [Synthesis]
In a 250 mL single neck flask, 3,4-dimethoxyphenethylamine (18.1 g, 100 mmol), paraformaldehyde (3.6 g, 120 mmol) and anhydrous ethanol (30 mL) were added sequentially. Upon completion of the reaction, the mixture was cooled to room temperature and white crystals were collected by filtration to yield 14.2 g of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride in 61.8% yield. | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 20, p. 5285 - 5289
[2] Patent: CN107573325, 2018, A. Location in patent: Paragraph 0109; 0110; 0111
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 9, p. 2420 - 2427
[4] Pharmazie, 1990, vol. 45, # 6, p. 408 - 410
[5] Journal of the American Chemical Society, 1934, vol. 56, p. 1769 |
| Spectrum Detail | Back Directory | [Spectrum Detail]
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)1HNMR
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)IR
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)Raman
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride(2328-12-3)FT-IR
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| Well-known Reagent Company Product Information | Back Directory | [Alfa Aesar]
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride, 97%(2328-12-3) | [Sigma Aldrich]
2328-12-3(sigmaaldrich) | [TCI AMERICA]
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline Hydrochloride,>98.0%(T)(2328-12-3) |
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