| Identification | More | [Name]
4-CHLORO-3-FLUOROBENZYL BROMIDE | [CAS]
206362-80-3 | [Synonyms]
4-Chloro-3-fluorobenzyl bromide 97%
4-Chloro-3-fluorobenzylbromide97% | [Molecular Formula]
C7H5BrClF | [MDL Number]
MFCD04115859 | [Molecular Weight]
223.48 | [MOL File]
206362-80-3.mol |
| Chemical Properties | Back Directory | [Melting point ]
30-33℃ | [Boiling point ]
227.1±25.0 °C(Predicted) | [density ]
1.654±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Sealed in dry,Room Temperature | [solubility ]
soluble in Methanol | [form ]
powder to lump | [color ]
White to Light yellow to Light orange | [Sensitive ]
Lachrymatory | [CAS DataBase Reference]
206362-80-3(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
34 | [Safety Statements ]
26-36/37/39-45 | [RIDADR ]
3261 | [Hazard Note ]
Corrosive/Lachrymatory | [HazardClass ]
8 | [HazardClass ]
CORROSIVE | [PackingGroup ]
Ⅱ | [HS Code ]
29039990 |
| Hazard Information | Back Directory | [Chemical Properties]
White solid | [Synthesis]
Step 1: Bromine (16.5 g, 0.103 mol) was added dropwise to a solution of triphenylphosphine (27.8 g, 0.103 mol) in dichloromethane (200 mL) at 0°C while stirring. After the dropwise addition was completed, stirring of the reaction mixture was continued for 10 minutes. Subsequently, 4-chloro-3-fluorobenzyl alcohol (15.8 g, 0.098 mol) was added and the reaction mixture was stirred for 30 minutes. Upon completion of the reaction, the reaction was quenched with ethanol and the mixture was poured into saturated sodium bicarbonate solution and extracted with dichloromethane. The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated. Purification by silica gel column chromatography afforded 4-(bromomethyl)-1-chloro-2-fluorobenzene (18.6 g, 85% yield).1H-NMR (400 MHz, CDCl3): δ = 7.27 (t, J = 7.9 Hz, 1H), 7.10 (dd, J = 7.9 Hz, 2.1 Hz, 1H), 7.04-6.99 (m, 1H). 4.32 (s, 2H). | [References]
[1] Patent: EP2952510, 2015, A1. Location in patent: Paragraph 0185 |
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