| Identification | Back Directory | [Name]
Aminooxy-PEG8-methane | [CAS]
2055024-52-5 | [Synonyms]
m-PEG8-Aminooxy
Aminooxy-PEG8-methane
Aminooxy-PEG8-methane HCl salt
Hydroxylamine, O-3,6,9,12,15,18,21,24-octaoxapentacos-1-yl- | [Molecular Formula]
C17H37NO9 | [MDL Number]
MFCD31813564 | [MOL File]
2055024-52-5.mol | [Molecular Weight]
399.48 |
| Hazard Information | Back Directory | [Description]
Aminooxy-PEG8-methane is a water soluble PEG reagent containing an aminooxy group and a methane group. The aminooxy group can be used in bioconjugation. It reacts with an aldehyde to form an oxime bond. If a reductant is used, it will form a hydroxylamine linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended. | [Uses]
Aminooxy-PEG8-methane is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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