| Identification | Back Directory | [Name]
8-Bromo-4-chromanone | [CAS]
204377-88-8 | [Synonyms]
8-Bromo-4-chromanone
8-bromo-chroman-4-one
8-BroMo-4-chroManone 97%
8-broMo-2,3-dihydrochroMen-4-one
8-bromo-2,3-dihydro-4H-chromen-4-one
8-BROMO-2,3-DIHYDRO-1-BENZOPYRAN-4-ONE
8-Bromo-2,3-dihydro-4H-1-benzopyran-4-one
8-broMo-3,4-dihydro-2H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 8-bromo-2,3-dihydro- | [EINECS(EC#)]
1312995-182-4 | [Molecular Formula]
C9H7BrO2 | [MDL Number]
MFCD09744046 | [MOL File]
204377-88-8.mol | [Molecular Weight]
227.05 |
| Hazard Information | Back Directory | [Synthesis]
Step 3: Synthesis of 8-bromo-benzotetrahydropyran-4-one (P34c)
Compound P34b (2.0 g, 8.15 mmol) was dissolved in ethylene glycol (20 mL) and heated to reflux for 4 hours. After completion of the reaction, the reaction mixture was cooled, poured into water and extracted twice with ether (Et2O). The organic layers were combined and washed sequentially with 1 M aqueous sodium hydroxide (NaOH) and saturated aqueous ammonium bicarbonate (NH4HCO3). The organic layers were dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated, and finally purified by column chromatography (eluent: petroleum ether/ethyl acetate = 50/1) to afford the target compound P34c (0.88 g, 48% yield) as a yellow solid. | [References]
[1] Patent: WO2012/139775, 2012, A1. Location in patent: Page/Page column 60-61 |
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