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ChemicalBook--->CAS DataBase List--->187218-90-2

187218-90-2

187218-90-2 Structure

187218-90-2 Structure
IdentificationBack Directory
[Name]

SRA880
[CAS]

187218-90-2
[Synonyms]

SRA880 free base
[Molecular Formula]

C26H32N4O4
[MOL File]

187218-90-2.mol
[Molecular Weight]

464.56
Chemical PropertiesBack Directory
[Boiling point ]

684.2±55.0 °C(Predicted)
[density ]

1.238±0.06 g/cm3(Predicted)
[pka]

9.08±0.40(Predicted)
Hazard InformationBack Directory
[Description]

SRA880 is a non-peptide somatostatin sst(1) receptor antagonist. SRA880 displayed significantly lower affinity for the other human recombinant somatostatin receptors ( pK(d) < or = 6.0) or a wide range of neurotransmitter receptors, except for the human dopamine D4 receptors. SRA880 positively modulates release of endogenous SRIF, was found to synergize with imipramine in causing antidepressant-like effects in the tail suspension test.
[Uses]

SRA880 (free base) is a compound with antidepressant-modulating effects. It is a somatostatin-1 autoreceptor antagonist that can synergize with imipramine to produce antidepressant-like effects and affect BDNF mRNA expression and phosphorylation of related proteins.
[References]

[1] Neuropeptidomics of mouse hypothalamus after imipramine treatment reveal somatostatin as a potential mediator of antidepressant effects DOI:10.1016/j.neuropharm.2011.08.004
187218-90-2 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354 , +17819995354
Website: https://www.targetmol.com/
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
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