| Identification | Back Directory | [Name]
Scabertopin | [CAS]
185213-52-9 | [Synonyms]
Scabertopin
Gpr52 antagonist E7
(Scabertopin)
2-Butenoic acid, 2-methyl-, (3aR,4S,9S,11E,12aR)-2,3,3a,4,5,9,10,12a-octahydro-11-methyl-3-methylene-2,7-dioxo-7H-9,6-methenofuro[2,3-f]oxacycloundecin-4-yl ester, (2Z)- | [Molecular Formula]
C20H22O6 | [MDL Number]
MFCD22417325 | [MOL File]
185213-52-9.mol | [Molecular Weight]
358.39 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from Elephantopus scaber. | [Uses]
Scabertopin is a sesquiterpene lactone. Scabertopin has been found to be prominent anticancer constituents[1][2]. | [Health effects]
Didancao species lactone has anti-tumor effect: Didancao has inhibitory effect on the proliferation of various tumor cells. | [Biological Activity]
Scabertopin, isolated from Elephantopus scaber, is a sesquiterpene lactone. It is an important anticancer ingredient. | [References]
[1] Liang QL, et al. [Structure modification on sesquiterpene lactones from Elephantopus scaber]. Yao Xue Xue Bao. 2007 Nov;42(11):1159-61. PMID:18300472
[2] Hiradeve SM, et al. A review on pharmacology and toxicology of Elephantopus scaber Linn. Nat Prod Res. 2014;28(11):819-30. DOI:10.1080/14786419.2014.883394 |
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