| Identification | More | [Name]
Methyl 4-(aminomethyl)benzoate | [CAS]
18469-52-8 | [Synonyms]
4-(AMINOMETHYL)BENZOIC ACID METHYL ESTER
4-(AMINOMETHYL)BENZOIC ACID METHYL ESTER HYDROCHLORIDE
4-METHOXYCARBONYL-BENZYLAMINE HYDROCHLORIDE
BUTTPARK 33\11-77
METHYL 4-(AMINOMETHYL)BENZOATE HYDROCHLORIDE
4-Aminomethylbenzoic acid methyl ester(HCl) | [Molecular Formula]
C9H11NO2 | [MDL Number]
MFCD00182671 | [Molecular Weight]
165.19 | [MOL File]
18469-52-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
243 °C (dec.)(lit.) | [Boiling point ]
278.7±23.0 °C(Predicted) | [density ]
1.121±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | [pka]
8.67±0.10(Predicted) | [Appearance]
White to off-white Solid | [CAS DataBase Reference]
18469-52-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
Methyl 4-aminomethylbenzoate is mainly used as an intermediate in organic synthesis, especially in the fields of medicine and chemical research. | [Synthesis]
Thionyl chloride (473 g, 3.97 mol) was added slowly and dropwise to a solution of 4-(aminomethyl)benzoic acid (300 g, 1.98 mol) in methanol (5 L). The reaction mixture was heated and refluxed for 6 h. After completion of the reaction, the solvent was removed by distillation under reduced pressure to give the crude product. The crude product was purified by acid-base treatment to finally obtain methyl 4-(aminomethyl)benzoate (300 g, 92% yield) in liquid form. | [References]
[1] Patent: US2008/51397, 2008, A1. Location in patent: Page/Page column 23
[2] Patent: US2007/149802, 2007, A1. Location in patent: Page/Page column 2-3
[3] Patent: WO2005/12280, 2005, A1. Location in patent: Page/Page column 51-52
[4] Patent: EP1541549, 2005, A1. Location in patent: Page/Page column 25; 42
[5] European Journal of Inorganic Chemistry, 2013, # 7, p. 1149 - 1156 |
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