| Identification | More | [Name]
D-Aspartic acid | [CAS]
1783-96-6 | [Synonyms]
D-2-AMINOBUTANEDIOIC ACID
D-AMINOSUCCINIC ACID
D-ASP
D-ASPARAGINIC ACID
D-(-)-ASPARTIC ACID
D-ASPARTIC ACID
H-D-ASP-OH
(R)-2-AMINOSUCCINIC ACID
(R)-(-)-AMINOSUCCINIC ACID
(R)-AMINOSUCCINIC ACID
(R)-(-)-ASPARTIC ACID
1-Amino-1,2-carboxyethane
d-aspartic
d-asparticaci
l-Asparagic acid
(R)-(-)-Aminosuccinic acid(R)-2-Aminosuccinic acid
D-ASPARTIC ACID CRYSTALLINE
D0001H-D-Asp-Oh
D-Aminosuccinicacid=H-D-Asp-OH
D(-)-Aspartic acid, 99+% | [EINECS(EC#)]
217-234-6 | [Molecular Formula]
C4H7NO4 | [MDL Number]
MFCD00063081 | [Molecular Weight]
133.1 | [MOL File]
1783-96-6.mol |
| Chemical Properties | Back Directory | [Appearance]
White or almost white crystalline powder | [Melting point ]
>300 °C(lit.)
| [alpha ]
-25.8 º (c=5, 5N HCl) | [Boiling point ]
245.59°C (rough estimate) | [density ]
1.66 | [refractive index ]
-25 ° (C=8, 50% HCl) | [storage temp. ]
Store at RT. | [solubility ]
Aqueous Acid (Sparingly) | [form ]
Crystalline Powder | [pka]
pK1: 1.89(0);pK2: 3.65;pK3: 9.60 (25°C) | [color ]
White to off-white | [Optical Rotation]
[α]20/D 24°, c = 2.3 in 6 M HCl | [Water Solubility ]
SOLUBLE | [Detection Methods]
T,NMR,Rotation | [Merck ]
14,840 | [BRN ]
1723529 | [InChIKey]
CKLJMWTZIZZHCS-UWTATZPHSA-N | [LogP]
-1.075 (est) | [CAS DataBase Reference]
1783-96-6(CAS DataBase Reference) | [NIST Chemistry Reference]
D-aspartic acid(1783-96-6) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [RTECS ]
CI9097500
| [HS Code ]
29224900 |
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white crystalline powder | [Uses]
A non-essential amino acid found in food sources and dietary supplements. D-Aspartic acid's conjugate base D-aspartate has potential use as a a therapeutic agent in the treatment of schizophrenia-related symptoms.
| [Definition]
ChEBI: The D-enantiomer of aspartic acid. | [reaction suitability]
reaction type: solution phase peptide synthesis | [Biological Activity]
Endogenous NMDA receptor agonist with similar activity to the L-isomer (L-Aminosuccinic acid ). Also a non-metabolizable substrate for EAA uptake systems. Modulates melatonin synthesis in the pineal gland. | [Synthesis]
In a reaction vessel, 4.85 g (0.03 mol) of dimethyl (S)-2-aminosuccinate was added to 50 mL of 6 M potassium hydroxide solution and the hydrolysis reaction was carried out by heating and refluxing for 3 hrs. Upon completion of the reaction, the pH of the reaction solution was adjusted to 6.5 with 6 N hydrochloric acid.The reaction solution was purified by passing it through a regenerated cation exchange resin column and the effluent with pH=4 was collected. The collected effluent was concentrated under reduced pressure to one-fifth of the original volume and then precipitated by adding 95% methanol. The precipitate was collected by filtration and dried to give 3.3 g of D-aspartic acid in 82.5% yield. | [storage]
Room temperature | [References]
[1] Patent: CN105503628, 2016, A. Location in patent: Paragraph 0026 |
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