| Identification | More | [Name]
2,6-DICHLORO-4-NITROANISOLE | [CAS]
17742-69-7 | [Synonyms]
1,3-DICHLORO-2-METHOXY-5-NITROBENZENE
2,6-DICHLORO-4-NITROANISOLE
4-Nitro-2,6-dichloroanisole
3,5-Dichloro-4-methoxynitrobenzene
1,3-Dichloro-2-Methoxy-5-Nitro
2,6-DICHLORO-4-NITROANISOLE 99%
1,3-DICHLORO-2-METHOXY-5-NITROBENZENE,99% | [EINECS(EC#)]
403-350-6 | [Molecular Formula]
C7H5Cl2NO3 | [MDL Number]
MFCD00061129 | [Molecular Weight]
222.03 | [MOL File]
17742-69-7.mol |
| Chemical Properties | Back Directory | [Appearance]
slightly beige crystals | [Melting point ]
97-100 °C | [Boiling point ]
305.6±37.0 °C(Predicted) | [density ]
1.5223 (rough estimate) | [refractive index ]
1.6140 (estimate) | [Fp ]
160 °C
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Sparingly), Chloroform (Slightly) | [form ]
Solid | [color ]
Pale Yellow to Yellow | [CAS DataBase Reference]
17742-69-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
N-T,T,N | [Risk Statements ]
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R25:Toxic if swallowed. | [Safety Statements ]
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
2811 | [Hazard Note ]
Toxic | [HazardClass ]
IRRITANT | [PackingGroup ]
III | [HS Code ]
29049095 |
| Hazard Information | Back Directory | [Chemical Properties]
slightly beige crystals | [Uses]
2,6-Dichloro-4-nitroanisole can be used for thyroid hormone receptor agonists. | [Synthesis Reference(s)]
The Journal of Organic Chemistry, 28, p. 1656, 1963 DOI: 10.1021/jo01041a056 | [Synthesis]
GENERAL STEPS: To a stirred solution of 2,6-dichloro-4-nitrophenol (6.0 g, 28.84 mmol) in anhydrous DMF (60 mL) was added anhydrous K2CO3 (15.9 g, 115.36 mmol) and iodomethane (8.18 g, 57.69 mmol). The reaction mixture was stirred at 0°C and then gradually warmed up to 60°C and kept for 6 hours. After completion of the reaction, the mixture was cooled to room temperature and slowly poured into ice water to quench the reaction. The precipitated solid was collected by filtration and dried under vacuum to obtain the crude product. The crude product was purified by column chromatography using petroleum ether: ethyl acetate (85:15) as eluent to give 2.5 g (39.0% yield) of 1,3-dichloro-2-methoxy-5-nitrobenzene as an off-white solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 8.22 (s, 2H), 4.01 (s, 3H). | [References]
[1] Patent: WO2017/117239, 2017, A1. Location in patent: Page/Page column 42
[2] Journal of Organic Chemistry, 1963, vol. 28, p. 1656 - 1662
[3] Bulletin of the Chemical Society of Japan, 1994, vol. 67, # 10, p. 2639 - 2646 |
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