| Identification | More | [Name]
Dibenzyl phosphite | [CAS]
17176-77-1 | [Synonyms]
AURORA KA-1209
DIBENZYL PHOSPHITE
DIBENZYL PHOSPHONATE
O,O'-DIBENZYLPHOSPHINE
PHOSPHONIC ACID DIBENZYL ESTER
PHOSPHOROUS ACID DIBENZYL ESTER
Dibenzyl hydrogen phosphite
Phosphonic acid, bis(phenylmethyl) ester
Phosphorous acid, bis(phenylmethyl) ester
Bromine Hydride Acetic Acid
DIBENZYL PHOSPHITE, TECH.
Dipenzylphosphit
Dibenzyl phosphite, 80%, tech. | [EINECS(EC#)]
241-226-1 | [Molecular Formula]
C14H15O3P | [MDL Number]
MFCD00004774 | [Molecular Weight]
262.24 | [MOL File]
17176-77-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless to yellow liquid | [Melting point ]
0 to 5° | [Boiling point ]
110-120 °C/0.01 mmHg (lit.) | [density ]
1.187 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.555(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) | [form ]
Liquid | [color ]
Clear colorless to yellow | [Water Solubility ]
Soluble in DMSO, Methanol. Reacts with water. | [Sensitive ]
Air & Moisture Sensitive | [Merck ]
14,3014 | [BRN ]
1982794 | [InChIKey]
DYUGVWSETOTNKQ-UHFFFAOYSA-N | [CAS DataBase Reference]
17176-77-1(CAS DataBase Reference) | [NIST Chemistry Reference]
Dibenzyl phosphite(17176-77-1) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S37/39:Wear suitable gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN3278 | [WGK Germany ]
3
| [F ]
21 | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29209090 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to yellow liquid | [Uses]
Dibenzyl Phosphite is used in the preparation of phenylalkylphosphonamidates which are then used as probes for a hydrophobic binding register in prostate-specific membrane antigen. | [Uses]
In preparation of N-phosphorylated amines. | [Synthesis]
Example 15 Synthesis of dibenzylphosphonate 15: Phenol 14 (0.51 g, 0.95 mmol) was dissolved in CH3CN (8 mL) and Cs2CO3 (0.77 g, 2.37 mmol) and trifluoromethanesulfonate (0.8 g, 1.90 mmol) were added sequentially. The reaction mixture was stirred at room temperature for 1.5 h and then concentrated under reduced pressure to remove the solvent. The residue was subjected to liquid-liquid partitioning with EtOAc and saturated NaCl solution. The organic phase was dried over Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: 3% MeOH/CH2Cl2) to afford dibenzylphosphonate 15 (0.62 g, 80% yield) as a white solid. | [References]
[1] Patent: US2004/121316, 2004, A1
[2] Patent: US2005/239054, 2005, A1 |
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