| Identification | More | [Name]
4-N-Cbz-cyclohexanone | [CAS]
16801-63-1 | [Synonyms]
4-N-CBZ-AMINO-CYCLOHEXANONE
4-N-CBZ-CYCLOHEXANONE
(4-OXOCYCLOHEXYL)CARBAMIC ACID BENZYL ESTER
4-CARBOBENZOXY-AMINO-CYCLOHEXANONE
N-CBZ-4-AMINO-CYCLOHEXANONE
(4-OXOCYCLOHEXYL)CARBAMIC ACID BENZYL ESTER, 95+%
4-(Benzyloxycarbonylamino)cyclohexanone, 97%
(4-Oxocyclohexyl)carbamic acid benzyl ester, 4-(Benzyloxycarbonylamino)cyclohexanone, Benzyl 4-oxocyclohexylcarbamate
4-(Benzylpxycarbonylamino)cyclohexanone | [Molecular Formula]
C14H17NO3 | [MDL Number]
MFCD06658393 | [Molecular Weight]
247.29 | [MOL File]
16801-63-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
86-87°C | [Boiling point ]
427.3±44.0 °C(Predicted) | [density ]
1.17±0.1 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
solid | [pka]
11.98±0.20(Predicted) | [Appearance]
White to off-white Solid | [InChI]
InChI=1S/C14H17NO3/c16-13-8-6-12(7-9-13)15-14(17)18-10-11-4-2-1-3-5-11/h1-5,12H,6-10H2,(H,15,17) | [InChIKey]
VHXBIBFCJISKFA-UHFFFAOYSA-N | [SMILES]
C(OCC1=CC=CC=C1)(=O)NC1CCC(=O)CC1 | [CAS DataBase Reference]
16801-63-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36:Irritating to the eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3 | [HazardClass ]
IRRITANT | [HS Code ]
29242990 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 4-N-benzyloxycarbonylaminocyclohexanone from benzyl (trans-4-hydroxycyclohexyl)carbamate: synthesis of compound 120.3. Jones reagent (~10 mL) was added slowly and dropwise to a solution of compound 120.2 (7.0 g, 28.08 mmol, 1.00 eq.) in acetone (100 mL) at 0 °C. The reaction process was monitored by thin layer chromatography (TLC). After stirring the reaction mixture for 30 minutes, the reaction was quenched with saturated aqueous sodium bisulfite (NaHSO3) solution. Subsequently, extraction was performed with ethyl acetate (EtOAc, 3 x 100 mL). The organic layers were combined, washed with saturated aqueous sodium chloride (NaCl), dried over anhydrous sodium sulfate (Na2SO4), and finally concentrated under reduced pressure to give 5.0 g (72% yield) of compound 120.3 as a white solid. | [References]
[1] Journal of Organic Chemistry, 2012, vol. 77, # 6, p. 3005 - 3009
[2] Bioorganic and Medicinal Chemistry, 2010, vol. 18, # 10, p. 3387 - 3402
[3] Synthetic Communications, 1990, vol. 20, # 7, p. 1073 - 1082
[4] Patent: WO2014/194242, 2014, A2. Location in patent: Paragraph 00693; 00695
[5] Patent: WO2015/164374, 2015, A1. Location in patent: Paragraph 00288; 00290 |
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