| Identification | Back Directory | [Name]
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide | [CAS]
1646499-97-9 | [Synonyms]
ML 382
2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide
Benzamide, 2-[(cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)- | [Molecular Formula]
C18H20N2O4S | [MOL File]
1646499-97-9.mol | [Molecular Weight]
360.43 |
| Chemical Properties | Back Directory | [density ]
1.34±0.1 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [form ]
A solid | [pka]
8.30±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ML 382 acts as a potent and selective allosteric modulator of MrgX1, used in the stufy to improve the potency and efficacy of anti-chronic pain medicaments. | [Biological Activity]
ML382 is a positive allosteric modulator of Mas-related G-protein-coupled receptor X1 (MrgprX1MrgX1SNSR4)a G-protein coupled receptor (GPCR) selectively expressed in dorsal root ganglion (DRG) neurons. MrgX1 is believed to be a functional ortholog of mouse MrgC11which has been shown to be involved in itch and pain. ML382 is selective for MrgX1 over MrgX2MrgC11 and a panel of 68 other GPCRsion channels and transporterswith an EC50 value of 190 nm with an Emax value of 148% in the presence of the known ligand BAM8-22. | [in vivo]
ML382 (5 μM) significantly increases inhibition of ICa by a low concentration of BAM8–22 (0.5 μM) in DRG neurons from MrgprX1 mice. ML382 enhances the inhibition of spinal synaptic transmission by BAM8-22 in MrgprX1 mice. ML382 (25 μM, 125 μM, and 250 μM; 5 μL; i.th.;) dose-dependently attenuates heat hypersensitivity in MrgprX1 mice. ML382 (lumbar puncture injection; 25 μM, 5 μL) leads to a significant increase in postconditioning time spent in the ML382-paired chamber, compared with the preconditioning value. ML382 inhibits nerve injury-induced ongoing pain in MrgprX1 mice[1]. | [storage]
Store at RT |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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