| Identification | Back Directory | [Name]
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine | [CAS]
381168-77-0 | [Synonyms]
ML367
N-(3,4-difluorophenyl)-2-pyridin-4-ylquinazolin-4-amine
4-Quinazolinamine, N-(3,4-difluorophenyl)-2-(4-pyridinyl)- | [Molecular Formula]
C19H12F2N4 | [MOL File]
381168-77-0.mol | [Molecular Weight]
334.32 |
| Hazard Information | Back Directory | [Uses]
ML367 is a potent inhibitor of ATPase family AAA domain-containing protein 5 (ATAD5) stabilization, acts as a probe molecule that has low micromolar inhibitory activity. ML367 blocks DNA repair pathways, suppresses general DNA damage responses including RPA32-phosphorylation and CHK1-phosphorylation in response to UV irradiation[1]. | [Biological Activity]
ML367 is a potent micromolar inhibitor of the ATPase family AAA domain-containing protein 5 (ATAD5). It blocks DNA repair pathways and general DNA damage responses, including UV-stimulated phosphorylation of RPA32 and phosphorylation of CHK1. | [in vitro]
ML367 (0-40 μM, 16 hours) inhibits FLAG-ATAD5 stabilization in HEK293T cells in the presence or absence of 20 μM 5-FUrd. Western Blot Analysis < table class="zh_use_1"> | Cell Line: | HEK293T cells | | Concentration: | 0-40 μM in the presence or absence of 20 μM 5-Furd | | Incubation Time: | 16 hours | | Result: | Inhibited the increased ATAD5 protein levels induced by 5-Furd. | |
|
[target]
| Target | Value | ATAD5
() | [storage]
Store at -20°C | [References]
[1] Rohde JM, et al. Discovery of ML367, inhibitor of ATAD5 stabilization. Probe Reports from the NIH Molecular Libraries Program. PMID:24479200 |
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| Company Name: |
InvivoChem
|
| Tel: |
13549236410 |
| Website: |
https://www.invivochem.cn/ |
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Tags:381168-77-0
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