| Identification | More | [Name]
IMIDAZOLE HYDROCHLORIDE | [CAS]
1467-16-9 | [Synonyms]
ImidazoleHCl
Imidazole salt
Imidazolium chloride
midazole hydrochloride
IMIDAZOLE HYDROCHLORIDE
GLYOXALINE, HYDROCHLORIDE
1H-iMidazole hydrochloride
Imidazole hydrochloride 99%
1h-imidazole,monohydrochloride
1H-IMidazole,hydrochloride (1:1)
AMerican CustoM CheMicals Corporation
Imidazole hydrochloride≥ 99% (Titration)
1,3-DIAZA-2,4-CYCLOPENTADIENE HYDROCHLORIDE | [EINECS(EC#)]
604-535-6 | [Molecular Formula]
C3H5ClN2 | [MDL Number]
MFCD00012695 | [Molecular Weight]
104.54 | [MOL File]
1467-16-9.mol |
| Chemical Properties | Back Directory | [Appearance]
white powder | [Melting point ]
158-161 °C(lit.)
| [storage temp. ]
Store at RT. | [solubility ]
H2O: 50 mg/mL, clear, colorless
| [form ]
solid | [color ]
Pale yellow | [PH]
9.0-10.0 | [Stability:]
Stable. Hygroscopic. Incompatible with strong oxidizing agents. | [BRN ]
3678283 | [InChI]
InChI=1S/C3H4N2.ClH/c1-2-5-3-4-1;/h1-3H,(H,4,5);1H | [InChIKey]
JDIIGWSSTNUWGK-UHFFFAOYSA-N | [SMILES]
C1NC=NC=1.Cl | [CAS DataBase Reference]
1467-16-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/38:Irritating to eyes and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
3-10 | [HS Code ]
2933299090 |
| Hazard Information | Back Directory | [Chemical Properties]
white powder | [Uses]
Imidazole hydrochloride is a useful research chemical. | [Synthesis]
In a flask, 68.22 g of imidazole was suspended in 505 g of xylene. The mixture was heated to reflux and 5 g of the xylene/water azeotropic mixture was removed by distillation to achieve dehydration. Subsequently, the temperature of the reaction system was lowered to 66°C and 25.2 grams of phosgene was added dropwise at a rate of 50.4 grams/hour over 30 minutes. After about 15 minutes, the viscosity of the reaction mixture increased significantly, exhibiting a chewing gum-like consistency. During the phosgene dropwise addition, the by-product imidazole hydrochloride precipitated in the form of yellow globules. After maintaining this temperature and continuing stirring for 1 hour, the reaction temperature was raised to 130 °C, at which time the imidazole hydrochloride transformed into a brown molten state. The melt was discharged from the reaction system at 130°C and solidified to a dark green solid upon cooling. The supernatant xylene phase was cooled to 0 °C, the precipitated crystals were filtered and dried at 20 mbar and 50 °C. A white crystalline N,N'-carbonyl diimidazole with a small amount of black impurities (Hazen color number: 489) was finally obtained with a purity of 96.8%, corresponding to 70% of the theoretical yield. | [References]
[1] Patent: US2005/272937, 2005, A1. Location in patent: Page/Page column 4
[2] Patent: US2005/272937, 2005, A1. Location in patent: Page/Page column 4
[3] Patent: US2005/272937, 2005, A1. Location in patent: Page/Page column 3-4; 5 |
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