| Identification | More | [Name]
4-(2-Aminoethyl)-1-Boc-piperidine | [CAS]
146093-46-1 | [Synonyms]
4-(2-AMINOETHYL)-1-BOC-PIPERIDINE
4-(2-AMINO-ETHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
4-(AMINOETHYL)-1-BOC-PIPERIDINE
4-(AMINOETHYL)-1-N-BOC-PIPERIDINE
4-(2-Aminoethyl)-1-N-Boc-piperidine
tert-butyl 4-(2-aminoethyl)piperidine-1-carboxylate | [Molecular Formula]
C12H24N2O2 | [MDL Number]
MFCD04038459 | [Molecular Weight]
228.33 | [MOL File]
146093-46-1.mol |
| Chemical Properties | Back Directory | [Boiling point ]
316.0±15.0 °C(Predicted) | [density ]
1.010±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
semisolid | [pka]
10.43±0.10(Predicted) | [color ]
off-white to light yellow | [InChI]
InChI=1S/C12H24N2O2/c1-12(2,3)16-11(15)14-8-5-10(4-7-13)6-9-14/h10H,4-9,13H2,1-3H3 | [InChIKey]
LBQDLHPFISVBRU-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CCC(CCN)CC1 | [CAS DataBase Reference]
146093-46-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Symbol(GHS) ]
GHS07 | [Signal word ]
Warning | [Hazard statements ]
H302 | [Precautionary statements ]
P280-P305+P351+P338 | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
UN2811 | [HazardClass ]
IRRITANT | [HS Code ]
2933399990 |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-(N-Boc-4-piperidinyl)ethylamine from 1-Boc-4-(cyanomethyl)piperidine: tert-butyl 4-(cyanomethyl)piperidine-1-carboxylate (20 g, 89.29 mmol) and NH4OH (9 mL) were dissolved in methanol (200 mL) and Raney Ni (6 g, 101.69 mmol) was added. The reaction was carried out at 50°C for 5 h under H2 pressure of 50 psi. Upon completion of the reaction, the mixture was filtered through a diatomaceous earth pad and the filtrate was concentrated to afford the target product 2-(N-Boc-4-piperidinyl)ethylamine (20.5 g, 100%) as a colorless oil.1H NMR (400 MHz, CDCl3) δ 1.06-1.19 (m, 2H), 1.44 (d, J = 7.41 Hz, 2H), 1.47 (s 9H), 1.50-1.58 (m, 1H), 1.66 (d, J = 12.49 Hz, 2H), 2.09 (br.s., 2H), 2.70 (t, J = 12.29 Hz, 2H), 2.75-2.83 (m, 2H), 4.08 (br.s., 2H). | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 21, p. 4805 - 4811 |
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