| Identification | More | [Name]
THIAZOLE-2-CARBOXYLIC ACID | [CAS]
14190-59-1 | [Synonyms]
1,3-THIAZOLE-2-CARBOXYLIC ACID
RARECHEM AL BE 0750
THIAZOLE-2-CARBOXYLIC ACID
2-THIAZOLECARBOXYLIC ACID,THIAZOLE-2-CARBOXYLIC ACID | [Molecular Formula]
C4H3NO2S | [MDL Number]
MFCD02094169 | [Molecular Weight]
129.14 | [MOL File]
14190-59-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
91.6-93°C | [Boiling point ]
310.6±25.0 °C(Predicted) | [density ]
1.525±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [form ]
Solid | [pka]
2.95±0.10(Predicted) | [Appearance]
White to off-white Solid | [Water Solubility ]
Slightly soluble in water. | [Detection Methods]
NMR , T | [CAS DataBase Reference]
14190-59-1(CAS DataBase Reference) | [Storage Precautions]
Store under argon gas |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
1 | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
Beige to light yellow powder | [Uses]
Thiazole-2-carboxylic acid is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff. | [Synthesis]
General procedure for the synthesis of thiazole-2-carboxylic acid from ethyl 2-thiazolecarboxylate: 2N aqueous KOH solution (3.5 mL, 5 eq.) was added to a solution of ethyl 2-thiazolecarboxylate (213 mg, 1.355 mmol) in ethanol (3 mL) at 116 °C. The reaction mixture was stirred at room temperature for 2 hours and then acidified with 2N HCl (3.5 mL). The acidified mixture was allowed to stand overnight and needle-like crystals were precipitated and collected by filtration to give thiazole-2-carboxylic acid (43.3 mg, 25% yield). | [References]
[1] Patent: US2007/185056, 2007, A1. Location in patent: Page/Page column 49
[2] Helvetica Chimica Acta, 1945, vol. 28, p. 924
[3] Patent: WO2008/76243, 2008, A2. Location in patent: Page/Page column 75
[4] Patent: WO2008/85316, 2008, A1. Location in patent: Page/Page column 73
[5] Patent: WO2006/138373, 2006, A2. Location in patent: Page/Page column 128-129 |
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