| Identification | Back Directory | [Name]
2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE | [CAS]
141449-85-6 | [Synonyms]
2-Boc-hexahydro-pyrrpol[3...
4-c]pyrrole-2(1H)-carboxylate
tert-butyl hexahydropyrrolo[3
Pyrrolo[3,4-c]Pyrrole-2(1H)-Ca
2-Boc-octahydropyrrolo[3,4-c]pyrrole
2-Boc-Hexahydro-Pyrrol[3,4-c]Pyrrole
2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE
2-Boc-hexahydro-pyrrpol[3,4-c]pyrrole
Octahydropyrrolo[3,4-c]pyrrole, N2-BOC protected
2-BOC-HEXAHYDRO-PYRROLO[3,4-C]PYRROLE HYDROCHLORIDE
tert-Butyl octahydropyrrolo[3,4-c]pyrrole-2-carboxylate
HEXAHYDRO-PYRROLO[3,4-C]PYRROLE-2-CARBOXYLIC ACID TERT-BUTYL ESTER
tert-butyl 2,3,3a,4,6,6a-hexahydro-1H-pyrrolo[3,4-c]pyrrole-5-carboxylate | [Molecular Formula]
C11H20N2O2 | [MDL Number]
MFCD04115128 | [MOL File]
141449-85-6.mol | [Molecular Weight]
212.29 |
| Chemical Properties | Back Directory | [Boiling point ]
295.4±33.0 °C(Predicted) | [density ]
1.076±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
solid | [pka]
10.72±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
2-Boc-Hexahydro-pyrrolo[3,4-C]pyrrole is an organic synthetic intermediate compound used in the preparation of anticancer agent compounds and sigma-2 ligands. | [Synthesis]
Example 6C: Synthesis of tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate
To a solution of tert-butyl 5-benzylhexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (107.8 g, 0.356 mol), the product of Example 6B, in methanol (250 mL) was added wet 20% Pd(OH)2/C catalyst (10.8 g). The reaction mixture was hydrogenated for 2.5 hours at 50°C and 60 psi under a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford the title compound tert-butyl hexahydropyrrolo[3,4-c]pyrrole-2(1H)-carboxylate (74 g, 0.35 mol, 98% yield). Mass spectrum (DCI/NH3) m/z: 213 ([M+H]+). | [References]
[1] Patent: US2005/65178, 2005, A1. Location in patent: Page/Page column 22
[2] Patent: US2005/101602, 2005, A1. Location in patent: Page/Page column 28
[3] Patent: WO2009/111550, 2009, A1. Location in patent: Page/Page column 37
[4] Patent: WO2013/71697, 2013, A1. Location in patent: Paragraph 00250
[5] Patent: US2014/228361, 2014, A1. Location in patent: Paragraph 0371-0372 |
|
|