| Identification | More | [Name]
2',3',4'-TRIMETHOXYACETOPHENONE | [CAS]
13909-73-4 | [Synonyms]
2',3',4'-TRIMETHOXYACETOPHENONE
2,3,4-TRIMETHOXYACETOPHENONE
TIMTEC-BB SBB008574
1-(2,3,4-Trimethoxyphenyl)ethanone
Ethanone, 1-(2,3,4-trimethoxyphenyl)-
2-3-4-trimethxoyacetophenone
2',3',4'-Trimethoxyacetophenone 2,3,4-Tromethoxyacetophenone
2',3',4'-Trimethoxyacetophenone 97%
2,3,4-Tromethoxyacetophenone
2′,3′,4′-Trimethoxyacetophenone, GC 97% | [EINECS(EC#)]
237-678-4 | [Molecular Formula]
C11H14O4 | [MDL Number]
MFCD00008726 | [Molecular Weight]
210.23 | [MOL File]
13909-73-4.mol |
| Chemical Properties | Back Directory | [Appearance]
clear yellow liquid | [Melting point ]
14-15 °C(lit.) | [Boiling point ]
295-297 °C(lit.) | [density ]
1.155 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.5384(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [form ]
clear liquid | [color ]
Colorless to Light yellow to Light orange | [LogP]
1.630 | [CAS DataBase Reference]
13909-73-4(CAS DataBase Reference) | [EPA Substance Registry System]
|
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Safety Statements ]
S24/25:Avoid contact with skin and eyes . | [WGK Germany ]
3
| [RTECS ]
AN0531000 | [Hazard Note ]
Irritant | [HS Code ]
29145000 |
| Hazard Information | Back Directory | [Chemical Properties]
clear yellow liquid | [Uses]
2',3',4'-Trimethoxyacetophenone is an organic compound with a benzene ring and an acetyl group. 2',3',4'-Trimethoxyacetophenone can be used as a raw material for synthesizing dyes, fragrances, and certain pesticides[1]. | [Preparation]
Obtained by reaction of dimethyl sulfate with gallacetophenone in methanol in the presence of potassium hydroxide. | [General Description]
2′,3′,4′-Trimethoxyacetophenone on reaction with BCl3 gives the corresponding 2,3-dihydroxy-4-methoxy compounds. | [Synthesis]
To a solution of 2',3',4'-trihydroxyacetophenone (1.66 g, 10 mmol) in acetone (50 mL) was added potassium carbonate (11 g) and dimethyl sulfate (6 mL, 30 mmol). The reaction was stirred at 45 °C for 17 h. The reaction was terminated by the addition of water. The reaction mixture was filtered, neutralized with 1 M HCl and then extracted with dichloromethane (200 mL). The organic layer was washed with brine (150 mL) and the crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate, 5:1). Yield: 1.85 g (88%).1H NMR (CDCl3, 300 MHz) δ 7.50 (d, J = 8.8 Hz, 1H), 6.68 (d, J = 8.8 Hz, 1H), 3.94 (s, 3H), 3.89 (s, 3H), 3.85 (s, 3H), 2.58 (s, 3H) ppm.13C NMR ( CDCl3, 75 MHz) δ 198.01, 157.44, 154.30, 128.99, 125.78, 125.57, 106.99, 61.30, 60.80, 56.06, 30.97 ppm. Pharm. Bull. 1984, 32, 3354-3360. | [References]
[1] Lenz G R, et al. Synthesis of the novel isoquinoline enamide alkaloid polycarpine[J]. Journal of Heterocyclic Chemistry, 1981, 18(4): 691-693. |
| Spectrum Detail | Back Directory | [Spectrum Detail]
2',3',4'-TRIMETHOXYACETOPHENONE(13909-73-4)MS
2',3',4'-TRIMETHOXYACETOPHENONE(13909-73-4)1HNMR
2',3',4'-TRIMETHOXYACETOPHENONE(13909-73-4)13CNMR
2',3',4'-TRIMETHOXYACETOPHENONE(13909-73-4)IR1
2',3',4'-TRIMETHOXYACETOPHENONE(13909-73-4)Raman
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