| Identification | More | [Name]
1-(2-Methoxyethyl)piperazine | [CAS]
13484-40-7 | [Synonyms]
1-(2-METHOXYETHYL)PIPERAZINE
RARECHEM AH CK 0124
Methoxyethylpiperazine
1-(2-Methoxyethyl)piperazine 98%
1-(2-METHOXYETHYL)-PIPERAZINE >98% | [EINECS(EC#)]
627-897-7 | [Molecular Formula]
C7H16N2O | [MDL Number]
MFCD00191214 | [Molecular Weight]
144.21 | [MOL File]
13484-40-7.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless to yellow liquid | [Melting point ]
100-101 °C | [Boiling point ]
193-194 °C (lit.) | [density ]
0.970 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.4730(lit.)
| [Fp ]
188 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Liquid | [pka]
9.15±0.10(Predicted) | [color ]
Clear colorless to yellow | [Detection Methods]
GC,MS,NMR | [BRN ]
105098 | [InChIKey]
BMEMBBFDTYHTLH-UHFFFAOYSA-N | [CAS DataBase Reference]
13484-40-7(CAS DataBase Reference) | [Storage Precautions]
Air sensitive;Store under nitrogen |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns.
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN 2735 8/PG 3
| [WGK Germany ]
3
| [F ]
10-34 | [Hazard Note ]
Irritant | [HazardClass ]
8 | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅲ | [HS Code ]
29349990 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to yellow liquid | [Uses]
Reactant for:• ;Preparation of biologically and pharmacologically active molecules1,2,3,4,5 | [Synthesis]
Under nitrogen protection, 8.6 g (0.1 mol) of piperazine and 10.4 g of methanol were added to the reaction flask, 35 μl of hydrochloric acid (10.4 g, 0.1 mol) was added with stirring, and the internal temperature was controlled to 80 °C. Under the condition of keeping the internal temperature below 80 °C, 8.7 g (0.07 mol) of 2-bromoethanol was added slowly and dropwise over 0.5 h. Subsequently, the reaction was continued with stirring at the same temperature for 8 h. 36.9 g of colorless and transparent reaction solution was obtained. Gas chromatographic analysis showed a yield of 84.6% for N-(2-hydroxyethyl)piperazine, with a selectivity of 88.5% for N-(2-hydroxyethyl)piperazine, 7.7% for N,N'-bis(2-hydroxyethyl)piperazine, and 3.8% for the unknown component. Compared to the results of Example 2 in Table 1 , the reaction conditions were the same as in Example 2 when 3.8 g (0.04 mol) of 2-methoxyethyl ester was used in place of 2-bromoethanol. GC analysis showed a 70.1% yield of N-(2-methoxyethyl)piperazine with a selectivity of 83.4% for N-(2-methoxyethyl)piperazine, 15.0% for N,N'-bis(2-methoxyethyl)piperazine, and 1.6% for the unknown component. This result is consistent with the results of Example 5 in Table 1. | [References]
[1] Patent: JP5838628, 2016, B2. Location in patent: Paragraph 0056; 0059 |
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