| Identification | More | [Name]
2-Chloro-3-amino-4-methyl pyridine | [CAS]
133627-45-9 | [Synonyms]
2-CHLORO-3-AMINO-4-METHYLPYRIDINE
2-CHLORO-3-AMINO-4-PICOLINE
2-CHLORO-4-METHYLPYRIDIN-3-AMINE
2-CHLORO-4-METHYL-PYRIDIN-3-YLAMINE
3-AMINO-2-CHLORO-4-METHYLPYRIDINE
3-AMINO-2-CHLORO-4-PICOLINE
ASINEX-REAG BAS 13794917
TIMTEC-BB SBB010194
2-Chloro-3-Amino-4-Methylpyridine,Nevirapine
2-Chloro-3-Amino-4-Methylpyrid
2-chloro-3-amino-4-methylpyridine (intermediate of nevirapine)
3-Pyridinamine,2-chloro-4-methyl-(9CI)
2-CHLORO-4-METHYLPYRIDIN-3-AMINE ,98%
3-AMINO-2-CHLORO-4-PICOLINE (3-AMINO-2-CHLORO-4-METHYLPYRIDINE)
2-chloro-4-methylpyridin-3-amine(3-AMINO-2-CHLORO-4-PICOLINE)
3-Amino-2-chloro-4-methlpyridine
3-Amino-2-chloro-4-methylpyridine ,98% | [EINECS(EC#)]
603-756-5 | [Molecular Formula]
C6H7ClN2 | [MDL Number]
MFCD00673152 | [Molecular Weight]
142.59 | [MOL File]
133627-45-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Off White Crystals | [Melting point ]
65-70 °C | [Boiling point ]
283.3±35.0 °C(Predicted) | [density ]
1.260±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Chloroform, Ethanol | [form ]
Crystals | [pka]
3.22±0.10(Predicted) | [color ]
Off White | [Detection Methods]
GC,HPLC, | [InChI]
InChI=1S/C6H7ClN2/c1-4-2-3-9-6(7)5(4)8/h2-3H,8H2,1H3 | [InChIKey]
UOBCYTOUXLAABU-UHFFFAOYSA-N | [SMILES]
C1(Cl)=NC=CC(C)=C1N | [CAS DataBase Reference]
133627-45-9(CAS DataBase Reference) | [Storage Precautions]
Heat sensitive |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S36:Wear suitable protective clothing . | [RIDADR ]
UN2811 | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Chemical Properties]
Off White Crystals | [Uses]
3-Amino-2-chloro-4-methylpyridine, also known as CAPIC, is a key intermediate in the production of nevirapine, a non-nucleosidic reverse transcriptase inhibitor that has been established to be clinically useful for the treatment of infection by HIV-1. | [Preparation]
3-Amino-2-chloro-4-methylpyridine can be obtained by reacting 2-chloro-4-methylnicotinamide with strong bases and halides.
| [References]
[1] Xin Ge. “A concise synthesis of 2-chloro-3-amino-4-methylpyridine.” Research on Chemical Intermediates 37 6 (2011): 599–604. |
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