午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

ChemicalBook--->CAS DataBase List--->132489-69-1

132489-69-1

132489-69-1 Structure

132489-69-1 Structure
IdentificationBack Directory
[Name]

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI
[CAS]

132489-69-1
[Synonyms]

(Z)-Pugnac
(Z)-PUGNAc min. 99%
O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI
n-acetylglucosaminono-1,5-lactoneo-(phenylcarbamoyl)oxime
acetamidodeoxy-D-glucopyranosylideneamino phenylcarbamate
O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate
O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
(Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate ,97%
2-(AcetylaMino)-2-deoxy-N-[[(phenylaMino)carbonyl]oxy]-D-gluconiMidic Acid δ-Lactone
(1Z)-2-(Acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-D-gluconimidic acid delta-lactone
D-Gluconimidic acid, 2-(acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-, δ-lactone, (1Z)-
(5R,6R,7S,8R,Z)-6,7-Dihydroxy-8-(hydroxymethyl)-2,3-dioxo-N-((phenylcarbamoyl)oxy)-1,4-oxazocane-5-carbimidic acid
[EINECS(EC#)]

1533716-785-6
[Molecular Formula]

C15H19N3O7
[MDL Number]

MFCD00145022
[MOL File]

132489-69-1.mol
[Molecular Weight]

353.33
Chemical PropertiesBack Directory
[Melting point ]

172-175°C
[density ]

1.53
[storage temp. ]

-20°C
[solubility ]

Soluble in DMSO (up to 35 mg/ml)
[form ]

solid
[pka]

11.85±0.70(Predicted)
[color ]

White
[BRN ]

4274031
[Stability:]

Moisture and Temperature Sensitive
Safety DataBack Directory
[WGK Germany ]

3
[HS Code ]

29329990
Hazard InformationBack Directory
[Description]

Proteins can be modified post-translationally by the addition of O-linked N-acetylglucosamine (O-GlcNAc). Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a β-N-acetylglucosaminidase that removes GlcNAc from O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that reversibly inhibits NCOAT (Ki = 40-110 nM). It also less potently inhibits other hexosaminidases and exochitinases. (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both in vitro and in cells.
[Chemical Properties]

White to Off-White Solid
[Uses]

O-(2-acetamido-2deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc) has been used to evaluate the effects of silibinin on O-GlcNAc levels of glycoproteins in Adult Retinal Pigment Epithelial-19 (ARPE-19) cells. It has also been used as a component of the HEPES lysis buffer for rat brain samples.
[Uses]

An inhibitor of O-GlcNAcase, hexosaminidase A, and hexosaminidase B
[Biological Activity]

O -GlcNAc- β - N -acetylglucosaminidase ( O -GlcNAcase) and β -hexosaminidase inhibitor (K i values are 46 and 36 nM respectively) that increases O -GlcNAc levels ~ 2-fold in HT29 cells. Z -linked isomer is more potent than the E isomer.
[Biochem/physiol Actions]

O-(2-acetamido-2deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate (PUGNAc) induces insulin resistance in 3T3-L1 adipocytes by reducing insulin-prompting phosphorylation of protein kinase B (Akt) and glycogen synthase kinase 3β (GSK3β).
[storage]

Desiccate at -20°C
[References]

1) Macauley et al. (2005), O-GlcNAcase uses substrate-assisted catalysis: kinetic analysis and development of highly selective mechanism-inspired inhibitors; J. Biol. Chem., 280 25313 2) Kneass and Marchase (2005), Protein O-GlcNAc modulates motility-associated signaling intermediates in neutrophils; J. Biol. Chem., 280 14579 3) Zou et al. (2007), The protective effects of PUGNAC on cardiac function after trauma-hemorrhage are mediated via increased protein O-GlcNAc levels; Shock, 27 402 4) Arias et al. (2004), Prolonged incubation in PUGNAc results in increased protein O-Linked glycosylation and insulin resistance in rat skeletal muscle; Diabetes, 53 921
132489-69-1 suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Website: www.atkchemical.com
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695 , +8613203830695
Website: www.coreychem.com/
Company Name: BOC Sciences
Tel: +1-631-485-4226
Website: www.bocsci.com/
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
Website: www.targetmol.com/
Company Name: ANHUI WITOP BIOTECH CO., LTD
Tel: +8615255079626 , +8615255079626
Website: www.yuhua99.com/showsupplierproductslist418627/0_en.htm
Company Name: Finetech Industry Limited
Tel: +86-27-8746-5837 +8619945049750 , +8619945049750
Website: https://www.finetechnology-ind.com/
Company Name: Wuhan Fortuna Chemical Co., Ltd
Tel: +86-027-59207850 +86-13986145403; , +86-13986145403;
Website: http://www.fortunachem.com/
Company Name: Wuhan Topule Biopharmaceutical Co., Ltd
Tel: +8618327326525 , +8618327326525
Website: topule.com/
Company Name: Zibo Hangyu Biotechnology Development Co., Ltd
Tel: +86-0533-2185556 +8615965530500 , +8615965530500
Website: www.yuhua99.com/manufacturer/hangyu-chemical-25178/
Company Name: Nanjing Bicbiotechnology Co., Ltd
Tel: +86-2552131256 +86-18251840740 , +86-18251840740
Website: www.bicbiotech.com/en/
Company Name: Aladdin Scientific
Tel:
Website: www.aladdinsci.com/
Company Name: Watson Biotechnology Co.,Ltd
Tel: +86-18186686046 +86-18186686046 , +86-18186686046
Website: http://www.yuhua99.com/manufacturer/cnwhwatson/
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873 , +86-86-13650506873
Website: http://www.chemdad.com/
Company Name: ChemeGen(Shanghai) Biotechnology Co.,Ltd.  Gold
Tel: 18818260767
Website: http://www.chemegen.com
Company Name: Beijing konoscience Technology Ltd.  Gold
Tel: 010-56034419 13426091577
Website: http://www.konoscience.com/
Company Name: Shanghai Tachizaki Biomedical Research Center  Gold
Tel: 18014399201
Website: http://www.chemlab-tachizaki.com/
Company Name: J & K SCIENTIFIC LTD.  
Tel: 18210857532
Website: www.jkchemical.com
Company Name:   
Tel: 821-50328103-801 18930552037
Website: http://www.yuhua99.com/ShowSupplierProductsList13285/0.htm
Tags:132489-69-1 Related Product Information
5142-23-4 51805-45-9 870281-82-6 765260-45-5 10576-12-2

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.