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ChemicalBook--->CAS DataBase List--->765260-45-5

765260-45-5

765260-45-5 Structure

765260-45-5 Structure
IdentificationBack Directory
[Name]

PHOSPHATIDYLETHANOL
[CAS]

765260-45-5
[Synonyms]

PHOSPHATIDYLETHANOL
1-PALMITOYL-2-OLEOYL-SN-GLYCERO-3-PHOSPHOETHANOL
[Molecular Formula]

C41H79O9P
[MDL Number]

MFCD00211162
[MOL File]

765260-45-5.mol
[Molecular Weight]

747.03
Chemical PropertiesBack Directory
[storage temp. ]

-20°
[solubility ]

Soluble in Chloroform (up to 10 mg/ml).
[form ]

Viscous oil / waxy solid
[Stability:]

Stable for 2 years from date of purchase as supplied. Phosphatidylethanol is subject to oxidation and must be protected from exposure to air. Solutions in chloroform may be stored at -20° for up to 3 months.
Hazard InformationBack Directory
[Description]

Phosphatidlyethanol is an endogenous metabolite of phosphatidylcholine. Phospholipase D converts phosphatidylcholine to phosphatidylethanol in the presence of ethanol. This reaction is the basis of a sensitive and selective assay for PLD activity in intact cells for which this product may be used as a chromatographic standard.
[References]

1) Kobayashi et al. (1987), Phosphatidylethanol formation via transphosphatidylation by rat brain synaptosomal phospholipase D; J. Neurochem., 48 1597 2) Liscovith et al. (1989), Phosphatidylethanol biosynthesis in ethanol-exposed NG108-15 neuroblastoma X glioma hybrid cells. Evidence for activation of a phospholipase D phosphatidyl transferase activity by protein kinase C; J. Biol. Chem., 264 1450 3) Pai et al. (1988), Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes; J. Biol. Chem., 263 12472
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