3034-53-5

1461-22-9

121359-48-6

A hexane solution of n-butyllithium (6.14 mmol, 2.5 M) was slowly added dropwise to a stirred anhydrous ethyl ether solution of 2-bromothiazole (3.07 mmol) at 0 °C under argon protection. After 1 hour of reaction, the mixture was cooled to -78 °C, followed by the slow addition of anhydrous ether solution of tributyltin chloride (3.07 mmol). The mixture was stirred at -78°C overnight. After completion of the reaction, the mixture was poured into water (50 mL) and the aqueous layer was extracted with ether (3 x 30 mL). The organic layers were combined, dried with anhydrous magnesium sulfate, and concentrated under reduced pressure to remove the solvent to give 2-(tri-n-butylmethylstannyl)thiazole (L-01b) as a light brown oil in quantitative yield. The product was used directly for the synthesis of the subsequent compound L-01a without further purification.