| Identification | More | [Name]
4-Hydroxy-6-aminopyrimidine | [CAS]
1193-22-2 | [Synonyms]
4-AMINO-6-HYDROXYPYRIMIDINE
6-AMINOPYRIMIDIN-4(3H)-ONE
6-AMINOPYRIMIDIN-4-OL
6-amino-1H-pyrimidin-4-one
4(1H)-Pyrimidinone, 6-amino-(8CI,9CI)
6-Amino-3H-pyrimidin-4-one
6-AMINO-4-HYDROXYPYRIMIDINE
4-Hydroxy-6-aminopyrimidine
6-amino-4(1H)-Pyrimidinone (8CI,9CI)
4-Amino-6(1H)-oxopyrimidine
6-Amino-3,4-dihydropyrimidine-4-one
6-Amino-4(1H)-pyrimidinone
6-Amino-4(3H)-pyrimidinone
6-Aminopyrimidine-4(3H)-one | [EINECS(EC#)]
214-771-8 | [Molecular Formula]
C4H5N3O | [MDL Number]
MFCD00051502 | [Molecular Weight]
111.1 | [MOL File]
1193-22-2.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
262-264°C | [Boiling point ]
227.5±43.0 °C(Predicted) | [density ]
1.55±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO | [form ]
Solid | [pka]
10.04±0.40(Predicted) | [color ]
White | [BRN ]
112429 | [InChI]
InChI=1S/C4H5N3O/c5-3-1-4(8)7-2-6-3/h1-2H,(H3,5,6,7,8) | [InChIKey]
HFMLLTVIMFEQRE-UHFFFAOYSA-N | [SMILES]
C1=NC(N)=CC(=O)N1 | [CAS DataBase Reference]
1193-22-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [HazardClass ]
IRRITANT | [HS Code ]
2933599590 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Synthesis]
Step 2: 2-mercapto-4-amino-6-hydroxypyridine (mass ratio 1:15) was added to 25% ammonia, followed by the addition of activated nickel and titanium dioxide, wherein the molar ratio of 2-mercapto-4-amino-6-hydroxypyridine, activated nickel and titanium dioxide was 1:4:1.5. The mixture was heated to 90°C and the reaction was carried out at reflux for 5 hours. Upon completion of the reaction, the activated nickel and titanium dioxide were removed by thermal filtration. The filtrate was cooled to room temperature and the solid product was precipitated. The solid was washed with 30 mL of water and dried at 40 °C to afford 4-amino-6-hydroxypyrimidine in 98.4% yield. | [References]
[1] Patent: CN105218554, 2016, A. Location in patent: Paragraph 0023
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 9, p. 1918 - 1929
[3] Patent: EP1406911, 2016, B1. Location in patent: Paragraph 00382; 00383 |
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