| Identification | More | [Name]
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide | [CAS]
119018-29-0 | [Synonyms]
4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide
n-[2-[4-(aminosulfonyl)phenyl]ethyl]-3-ethyl-2,5-dihydro-4-methyl-2-oxo-1h-pyrrole-1-carboxamide
N-[2-[4-(AMINOSULFONYL)PHENYL]ETHYL]-3-ETHYL-4-METHYL-2-OXO-1H-PYRROLE-1-CARBOXAMIDE
4-(2-(3-Ethyl-4-Methyl-2-Oxo-3-Pyrroline-1-Carboxamido)-Ethyl)-Benzenesulfonyl A
4-[2-(3-Ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamidoethyl]benzenesulfonamide
N-[4-2-(3-Ethyl-4-Methyl-2-Oxo-3-Pyrroline-1-Carboxamido)-Ethyl]Benzensulfonamide
Glimepiride sulfonamide
4-[2-(3-ethyl-4-methyl-2-oxo-3-pyrroline-1-carboxamido)ethyl]benezenesulfonamide
SulfonamideofGlimepiride
4-[2-(3-ETHYL-4-METHYL-2-OXO-3-PYRROLINE-1-CARBOXAMINDO)ETHYL]BENZENESULFONAMIDE
3-Ethyl-2,5-dihydro-4-methyl-N-{2-[4-(aminosulfonyl)phenyl]ethyl}-2-oxo-1H-pyrrole--1-carboxamide
4-(2-(3-ETHYLMETHYL-2-CARBONYLPYRROLIDINYLAMINO)ETHYL)BENZENESULFONAMIDE
3-ETHYL-4-METHYL-2-OXO-N-(2-(P-AMINOSULFONYLPHENYL)ETHYL)-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE
N-[2-[4-(AMINOSULFONYL)PHENYL]-3-ETHYL-2,5-DIHYDRO-4-METHYL-2-OXO]-1H-PYRROLE-1-CARBOXAMIDE
Des[(trans-4-methylcyclohexyl)amino]carbonyl Glimepiride
4-(2-((3-ethyl-4-methyl-2-oxo-pyrrolin-1-yl)carboxamido)ethyl)benzenesulfonamide)
4-[2-(3-ethyl-4-methyl-2-oxy-3-pyrrolinyl-1-methylamide)benzene sulfonamide] | [EINECS(EC#)]
411-850-0 | [Molecular Formula]
C16H21N3O4S | [MDL Number]
MFCD08460214 | [Molecular Weight]
351.42 | [MOL File]
119018-29-0.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
177-179?C | [density ]
1.304 | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly, Sonicated) | [form ]
neat | [pka]
10.16±0.10(Predicted) | [color ]
White to Off-White | [Usage]
Intermediate for the preparation of Glimepiride | [InChI]
InChI=1S/C16H21N3O4S/c1-3-14-11(2)10-19(15(14)20)16(21)18-9-8-12-4-6-13(7-5-12)24(17,22)23/h4-7H,3,8-10H2,1-2H3,(H,18,21)(H2,17,22,23) | [InChIKey]
AJEMFZRCUKJSES-UHFFFAOYSA-N | [SMILES]
N1(C(NCCC2=CC=C(S(N)(=O)=O)C=C2)=O)CC(C)=C(CC)C1=O | [CAS DataBase Reference]
119018-29-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [HS Code ]
2935909550 |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
Intermediate for the preparation of Glimepiride | [Synthesis]
38.0 kg of methanol and 5.1 kg of industrial ammonia were sequentially added to a 100 L reactor and stirring was initiated. The crude wet product of Intermediate 2 was added slowly at 20-30°C and the reaction was maintained for 2 hours. The progress of the reaction was monitored by HPLC and after the reaction was complete, filtration was carried out and the filter cake was washed with deionized water. The obtained crude wet product of white Intermediate 3 was directly transferred to a 200 L reactor. Subsequently, 110.0 kg of methanol was added, the reaction temperature was raised and stirring was continued for 4 hours. After completion of the reaction, the mixture was cooled to 20-25 °C, the product was separated by filtration and dried to obtain 8.47 kg of white solid Intermediate 3 refined product, with purity >99% and interstitial isomer impurity content of 0.2% by HPLC. | [References]
[1] Tetrahedron Letters, 2003, vol. 44, # 26, p. 4853 - 4855
[2] Patent: WO2006/103690, 2006, A1. Location in patent: Page/Page column 7,14-15
[3] Patent: CN108383768, 2018, A. Location in patent: Paragraph 0101; 0102 |
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