Identification | Back Directory | [Name]
(1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride | [CAS]
1147103-42-1 | [Synonyms]
OHPE Hcl Telaprevir INT2 Telaprevir InterMediate -1 (1S,3R,6S)-Ethyl Octahydrocyclopenta[c] pyrrole-1-carboxylate HCL CYCLOPENTA(C)PYRROLE-1-CARBOXYLIC ACID,OCTAHYDRO-ETHYL ESTERHYDROCHLORIDE (1S,3aR,6aS)-ethyloctahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride Cyclopenta[c]pyrrole-1-carboxylic acid, octahydro-, ethyl ester, (1S,3aR,6aS)- (1S,3aR,6aS)-octahydro-, Cyclopenta[c]pyrrole-1-carboxylic acid ethyl ester HCl Ethyl (1S,3aR,6aS)-octahydrocyclopenta[c]pyrrole-1-carboxylate hydrochloride (1:1) (1S,3aR,6aS)-Octahydrocyclopenta[c]pyrrole-1-carboxylic acid ethyl ester hydrochloride Cyclopenta[c]pyrrole-1-carboxylic acid, octahydro-, ethyl ester, (1S,3aR,6aS)-, hydrochloride Cyclopenta[c]pyrrole-1-carboxylic acid, octahydro-, ethyl ester, hydrochloride (1:1), (1S,3aR,6aS)- | [Molecular Formula]
C10H17NO2.HCl | [MOL File]
1147103-42-1.mol | [Molecular Weight]
219.708 |
Chemical Properties | Back Directory | [storage temp. ]
Sealed in dry,Room Temperature | [Appearance]
White to off-white Solid | [InChI]
InChI=1/C10H17NO2.ClH/c1-2-13-10(12)9-8-5-3-4-7(8)6-11-9;/h7-9,11H,2-6H2,1H3;1H/t7-,8-,9-;/s3 | [InChIKey]
CHVSZCHUIDYZIU-ZIEWZEMVNA-N | [SMILES]
C([C@H]1NC[C@]2([H])CCC[C@]12[H])(=O)OCC.Cl |&1:1,4,9,r| |
Hazard Information | Back Directory | [Synthesis]
Compound A of the present invention can be prepared by a conventional aminoprotection method to obtain the known telaprevir intermediate A. In this method, when the aminoprotecting group P is a tert-butoxycarbonyl group, the procedure is as follows: under argon protection, compound I is slowly added to an ethyl acetate solution (69.9 g) containing 11 wt% hydrogen chloride cooled to 0°C. The reaction is carried out by stirring for 4 hours. After the addition was completed, the reaction system was warmed to 30-35°C and stirred continuously at this temperature for 4 hours to ensure complete reaction. Upon completion of the reaction, the reaction solution was concentrated to dryness by distillation under reduced pressure. Subsequently, methyl tert-butyl ether (80 mL) was added to the residue at room temperature, stirred for 1 hour and then filtered. The filter cake was dried under vacuum to constant weight to give a white to off-white solid, timosartan intermediate A, in a yield of 15.4 g with 99.5% HPLC purity. The overall four-step molar yield from compound II to intermediate A was 70%. | [References]
[1] Patent: CN106928123, 2017, A. Location in patent: Paragraph 0085-0089 |
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