| Identification | More | [Name]
3-CHLORO-3-METHYL-1-BUTYNE | [CAS]
1111-97-3 | [Synonyms]
3-CHLORO-3-METHYL-1-BUTYNE
3-CHLORO-3-METHYLBUT-1-YNE
3-CHLORO-3-METHYLBUTYNE
3-chloro-3-methyl-1-butyn
2-Chloro-2-methyl-3-butyne
3-Methyl-3-chloro-1-butyne | [EINECS(EC#)]
214-188-9 | [Molecular Formula]
C5H7Cl | [MDL Number]
MFCD00190221 | [Molecular Weight]
102.56 | [MOL File]
1111-97-3.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless to straw colored liquid | [Melting point ]
-61 °C (lit.) | [Boiling point ]
73-75 °C (lit.) | [density ]
0.913 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.418(lit.)
| [Fp ]
40 °F
| [storage temp. ]
Refrigerator (+4°C) | [solubility ]
Chloroform, Hexane (Slightly) | [form ]
Liquid | [color ]
Clear colorless to straw | [Specific Gravity]
0.91 | [InChI]
InChI=1S/C5H7Cl/c1-4-5(2,3)6/h1H,2-3H3 | [InChIKey]
QSILYWCNPOLKPN-UHFFFAOYSA-N | [SMILES]
C#CC(Cl)(C)C | [CAS DataBase Reference]
1111-97-3(CAS DataBase Reference) | [EPA Substance Registry System]
1-Butyne, 3-chloro-3-methyl- (1111-97-3) |
| Safety Data | Back Directory | [Hazard Codes ]
F,Xn,Xi | [Risk Statements ]
R11:Highly Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1993 3/PG 2
| [WGK Germany ]
3
| [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29032990 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to straw colored liquid | [Uses]
3-Chloro-3-methyl-1-butyne was used in preparation of:
- series of benzo[b]pyrano[2,3-i]xanthen-6-ones and benzo[b]pyrano[3,2-h]xanthen-7-ones
- 6-hydroxy-3,3-dimethyl-3H,7H-benzo[a]pyrano[3,2-h]xanthen-7-one
- 5-hydroxy-2,2-dimethyl-2H,6H-benzo[a]pyrano[2,3-i]xanthen-6-one
- 3,3-dimethyl-3Hbenzofuro[3,2-f][1]-benzopyran
| [Uses]
3-Chloro-3-methyl-1-butyne is a propargyl chloride used to alkylate methanol, ethanol, ammonia and amines to the corresponding propargylic ether and amines. | [Synthesis]
The process is shown in Figure 1. First, the chlorination reactor was turned on and a reflux condensing unit was installed. The reaction vessel was cooled to 10 °C, followed by the sequential addition of concentrated hydrochloric acid, zinc chloride and polyethylene glycol 600. 2-methyl-3-butyn-2-ol was mixed with sulphuric acid and slowly added dropwise to the reaction vessel when the reactor temperature dropped to 0 °C. The reaction temperature was maintained at 0 °C for 2 hours. After the dropwise addition was completed, the reaction temperature was maintained between 0 and 5°C for 2 hours. Upon completion of the reaction, the mixture was transferred to a washing kettle for washing. This was followed by stirring and standing for layering. After separation of the aqueous layer, the organic layer was transferred to the extraction kettle. After filtration and drying, 3-chloro-3-methyl-1-butyne was obtained (95% yield, 99% purity). | [References]
[1] Patent: CN107903181, 2018, A. Location in patent: Paragraph 0007-0008; 0036-0040; 0054; 0058
[2] Chemistry - A European Journal, 2005, vol. 11, # 1, p. 308 - 320
[3] Chemical Communications, 2013, vol. 49, # 39, p. 4346 - 4348
[4] Journal of Labelled Compounds and Radiopharmaceuticals, 1996, vol. 38, # 12, p. 1077 - 1081
[5] European Journal of Organic Chemistry, 2014, vol. 2014, # 36, p. 8029 - 8034 |
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