| Identification | More | [Name]
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride | [CAS]
103577-66-8 | [Synonyms]
2-HYDROXYMETHYL-3-METHYL-4-(2,2,2-THIFLUOROETHOXY)PYRIDINE
2-HYDROXYMETHYL-3-METHYL-4-(2,2,2-TRIFLUOROETHOXY) PYRIDINE
[3-METHYL-4-(2,2,2-TRIFLUORO-ETHOXY)-PYRIDIN-2-YL]-METHANOL
[3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)PYRIDIN-2-YL]METHONOL
3-Methyl-4-(2,2,2-Trifluoroethoxy)-2-Pyridinemethanol
2-hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethyoxy)pyridine hydrochloride
3-METHYL-4-(2,2,2-TRIFLUOROETHOXY)-2-PY&
2-Hydroxymethyl-3-Methyl-4-(2,2,2-Trifluoroethoxy)-2-Pyridine
2-Hydroxymethyl-3Methyl-4-
2-Hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine hydrochloride
3-Methyl-4-(2,2,2-trifluoroethoxy)pyridine-2-methanol | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C9H11ClF3NO2 | [MDL Number]
MFCD07368269 | [Molecular Weight]
257.64 | [MOL File]
103577-66-8.mol |
| Chemical Properties | Back Directory | [Melting point ]
93-94 °C(Solv: isopropyl ether (108-20-3); hexane (110-54-3)) | [Boiling point ]
273.6±40.0 °C(Predicted) | [density ]
1.303±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
13.17±0.10(Predicted) | [color ]
Pale Beige to Light Brown | [Stability:]
Light Sensitive | [CAS DataBase Reference]
103577-66-8(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Chemical Properties]
Brown Solid | [Uses]
Intermediate in the preparation of Lansoprazole (L175000) impurity. | [Synthesis]
e) 34.8 g of 2-acetoxymethyl-3-methyl-4-(trifluoroethoxy)pyridine (equivalent to 18.7 g, 0.071 mol) obtained in the previous step was used as raw material, which was dissolved in 15 ml of a solvent mixture of methanol/water (1:1) at room temperature. The pH of the reaction system was adjusted with 33% aqueous sodium hydroxide solution to 13. The reaction was carried out at a temperature of 25 to 30 °C and a pH range of 12.5 to 13.5 and the progress of the reaction was monitored by HPLC. Upon completion of the reaction, the reaction mixture was neutralized with 36% hydrochloric acid and subsequently extracted with dichloromethane. The organic layer was dried and concentrated to 60 ml. The yield of the product 2-hydroxymethyl-3-methyl-4-(2,2,2-trifluoroethoxy)pyridine was 95-97% as determined by HPLC. | [References]
[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 3, p. 438 - 450
[2] Patent: EP1681056, 2006, A1. Location in patent: Page/Page column 8 |
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