| Identification | More | [Name]
1-BENZYLPIPERIDINE-4-CARBOXYLIC ACID | [CAS]
10315-07-8 | [Synonyms]
BUTTPARK 33\04-90
Bzl-isonipecotic acid
1-BENZYL-ISONIPECOTIC ACID
N-BENZYL-ISONIPECOTIC ACID
1-benzylpiperidin-4-carboxylic acid
1-BENZYLPIPERIDINE-4-CARBOXYLIC ACID
N-Benzylpiperidine-4-carboxylic acid
N-Benzyl-4-Piperidinecarboxylic acid
1-BENZYL-4-PIPERIDINE CARBOXYLIC ACID
1-N-Benzyl-pipeidine-4-carboxylic acid
1-(phenylmethyl)-4-Piperidinecarboxylic acid
4-Piperidinecarboxylic acid, 1-(phenylMethyl)-
1-Benzylisonipecotic acid, 1-Benzyl-4-carboxypiperidine | [Molecular Formula]
C13H17NO2 | [MDL Number]
MFCD03371463 | [Molecular Weight]
219.28 | [MOL File]
10315-07-8.mol |
| Hazard Information | Back Directory | [Synthesis]
(b) Synthesis of 1-benzyl-4-piperidinecarboxylic acid: 4N aqueous sodium hydroxide solution (35 mL) was added to a solution of ethyl 1-benzyl-4-piperidinecarboxylate (16.1 g, 65.1 mmol) in tetrahydrofuran (70 mL). The reaction mixture was stirred at room temperature and 1,4-dioxane (70 mL) was added and stirring was continued overnight. Upon completion of the reaction, the pH of the reaction solution was adjusted to 7 with 2 N hydrochloric acid. subsequently, the solvent was removed by distillation under reduced pressure. The obtained residue was suspended in ethanol and the solid was collected by filtration. Finally, the filtrate was concentrated under reduced pressure to afford 1-benzyl-4-piperidine carboxylic acid (13.6 g, 95% yield). | [References]
[1] Bioorganic and Medicinal Chemistry Letters, 2009, vol. 19, # 17, p. 4980 - 4983
[2] Patent: EP1500643, 2005, A1. Location in patent: Page 18
[3] Journal of Medicinal Chemistry, 2005, vol. 48, # 20, p. 6491 - 6503
[4] Helvetica Chimica Acta, 1997, vol. 80, # 5, p. 1528 - 1551
[5] Patent: US6020368, 2000, A |
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