TERT-BUTYL-N-METHYLCARBAMATE synthesis
- Product Name:TERT-BUTYL-N-METHYLCARBAMATE
- CAS Number:16066-84-5
- Molecular formula:C6H13NO2
- Molecular Weight:131.17
24424-99-5
74-89-5
16066-84-5
General method: Di-tert-butyl dicarbonate ((Boc)2O, 1.0 mmol) was mixed with monomethylamine (1.0 mmol) and the reaction was carried out with stirring at room temperature for the reaction time as shown in Table 1.The progress of the reaction was monitored by thin layer chromatography (TLC). In most cases, the purity of the resulting Boc-protected tert-butyl methyl-carbamate was satisfactory and no further purification was required. In a few cases, the products needed to be purified by silica gel column chromatography (eluent ratio: ethyl acetate/petroleum ether = 1:2). All products were characterized by infrared spectroscopy (IR), nuclear magnetic resonance hydrogen spectroscopy (1H NMR) and their physical properties.
24424-99-5
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74-89-5
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16066-84-5
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Yield:16066-84-5 91%
Reaction Conditions:
at 20; for 0.5 h;Green chemistry;
Steps:
General Procedure for the Boc Protection of Amines
General procedure: To (Boc)2O (1.0 mmol), was added an amine (1.0 mmol)and the mixture was stirred at room temperature for the time indicated in Table 1. The progress of the reaction was monitored by TLC. In most cases, the BOC protected product was found to be sufficiently pure and did not require any further purification. In some cases the product was purified by silica gel column chromatography (1:2; EtOAc/ Petrolium ether).All products were characterized by IR, 1H NMR and their physical properties.
References:
Mojtahedi, Mohammad Majid;Niknejad, Nina;Veisi, Hojat [Letters in Organic Chemistry,2013,vol. 10,# 2,p. 121 - 125]
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16066-84-5
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$10.00/1g