tert-butyl 4-carbamoylpiperazine-1-carboxylate synthesis
- Product Name:tert-butyl 4-carbamoylpiperazine-1-carboxylate
- CAS Number:883554-88-9
- Molecular formula:C10H19N3O3
- Molecular Weight:229.28
64-19-7
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Yield:883554-88-9 46%
Reaction Conditions:
with potassium cyanate in water at 20; for 4 h;
Steps:
188.1 Step 1.
Preparation of t-butyl 4-carbamoylpiperazine-1-carboxylate
In a 100-ml flask, 500 mg (2.68 mmol) of t-butyl piperazine-1-carboxylate was dissolved in 5 ml of water, followed by stirring. 1.6 ml of acetic acid and 1.09 g (13.4 mmol, 5.0 eq) of potassium cyanate dissolved in water were added, followed by stirring at room temperature for 4 hours.
After completion of the reaction, a solid was obtained by filtration while washing with water.
The solid thus obtained was dissolved in dichloromethane, and then washed with water.
An organic layer was separated and washed with a NaCl aqueous solution, dehydrated and dried over MgSO4, and concentrated under reduced pressure to obtain 282 mg (46%) of a title compound.
References:
EP3135669,2017,A1 Location in patent:Paragraph 0474; 0475
1118-02-1
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