Sodium dichloroacetate synthesis
- Product Name:Sodium dichloroacetate
- CAS Number:2156-56-1
- Molecular formula:C2H3Cl2NaO2
- Molecular Weight:152.93
79-43-6
2156-56-1
General procedure for the synthesis of sodium dichloroacetate from dichloroacetic acid: Cl2CHCO2H (135 μL, 1.64 mmol) was dissolved in H2O (2 mL), treated with 1.00 M NaOH (1.60 mL, 1.60 mmol), and the reaction was stirred for 2 hours at room temperature. Upon completion of the reaction, the volatiles were removed under vacuum to give a pale yellow residue. The residue was suspended in acetone, the suspension was filtered, the resulting colorless solid was washed with acetone and finally dried under vacuum. Yield: 227 mg, 96% yield.
79-43-6
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$21.00/25g
2156-56-1
317 suppliers
$6.00/1g
Yield:2156-56-1 96%
Reaction Conditions:
with sodium hydroxide in water at 20; for 2 h;
Steps:
Sodium dichloroacetate, Na[Cl2CHCO2] (Chart S5).
A solution of Cl2CHCO2H (135 μL, 1.64 mmol) in H2O (2 mL) was treated with 1.00 M NaOH(1.60 mL, 1.60 mmol) and stirred at room temperature for 2 hours. Volatiles were then removedunder vacuum and the yellowish residue was suspended in acetone. The suspension was filtered andthe resulting colorless solid was washed with acetone and dried under vacuum. Yield: 227 mg, 96%.
References:
Biancalana, Lorenzo;Pampaloni, Guido;Zacchini, Stefano;Marchetti, Fabio [Journal of Organometallic Chemistry,2018,vol. 869,p. 201 - 211] Location in patent:supporting information