RARECHEM AL BF 0508 synthesis
- Product Name:RARECHEM AL BF 0508
- CAS Number:3989-35-3
- Molecular formula:C4H4N2O2S
- Molecular Weight:144.15
Yield:3989-35-3 99.9%
Reaction Conditions:
with hydrogenchloride at 65; for 16 h;
Steps:
A Step A: Methyl 1,2,3-thiadiazole-4-carboxylate.
1,2,3-Thiadiazole-4-carboxylic acid (1.0, 1g, 7.7 mmol) was added to HCl (1.25 M in MeOH, 10 mL) and the reaction mixture was stirred at 65 C for 16 h. The solvent was removed under reduced pressure and the resulting crude mixture was purified (FCC, SiO2, 0-100 % EtOAc in DCM) to provide the title compound (1.1g, 99.9%). MS (ESI): mass calcd. for C4H4N2O2S, 144.0; m/z found, 145 [M+H]+.1H NMR (300 MHz, CDCl3) δ 9.27 (s, 1H), 4.07 (s, 3H).
References:
WO2018/67786,2018,A1 Location in patent:Page/Page column 140
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