Olmutinib synthesis

4synthesis methods

Product Name:Olmutinib
CAS Number:1353550-13-6
Molecular formula:C26H26N6O2S
Molecular Weight:486.59

Synthetically, olmutinib can be accessed in two steps beginning with 2,4-dichloro-thieno[3,2-d]pyrimidine (147), which is commercially available and can be prepared in two steps from urea and 3-aminothiophene 2- carboxylate. Nucleophilic addition of N-(3-hydroxyphenyl)-2- propenamide (148) to 147 proceeded with complete regioselectivity via treatment with K2CO3 in warm DMSO, smoothly providing the desired diaryl ether 149 in 87% yield after crystallization from isopropanol and water. From 149, substitution with commercially available piperazinyl aniline 150 under acidic heating conditions (DMA, IPA, TFA, 90 °C) provided olmutinib in 82% yield. After recrystallization, olmutinib (XVI) was obtained in 60% overall yield and 99.1% purity.

16234-14-3 Synthesis

16234-14-3
285 suppliers
$3.00/1g

1353550-13-6
121 suppliers
$25.00/1mg

2-Chlorothieno[3,2-d]pyriMidin-4(3H)-one

1245811-20-4
40 suppliers
$44.00/100mg

1353550-13-6
121 suppliers
$25.00/1mg

References

2-Mercaptothieno[3,2-d]pyrimidin-4(1H)one

31895-77-9
9 suppliers
inquiry

1353550-13-6
121 suppliers
$25.00/1mg

References

176530-46-4 Synthesis

2-(Methylsulfanyl)thieno[3,2-d]pyrimidin-4(1H)one

176530-46-4
14 suppliers
$129.00/50mg

1353550-13-6
121 suppliers
$25.00/1mg

References

Olmutinib Related Search:

Enzalutamide Rivaroxaban CO-1686 Poziotinib (HM781-36B) Neratinib Tucatinib Anlotinib OMecaMtiv Mecarbil AZD-9291

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Olmutinib synthesis

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