Buparlisib Hydrochloride synthesis
- Product Name:Buparlisib Hydrochloride
- CAS Number:1312445-63-8
- Molecular formula:C18H22ClF3N6O2
- Molecular Weight:446.86
10244-24-3
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Yield:-
Steps:
Multi-step reaction with 3 steps
1: potassium acetate / tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium(0) / 2 h / 84 °C / Inert atmosphere
2: caesium carbonate / dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II) / water; tetrahydrofuran / 0.75 h / 45 °C / Inert atmosphere
3: hydrogenchloride / isopropyl alcohol; acetone / 2.25 h / Inert atmosphere
References:
WO2012/44727,2012,A2
106447-97-6
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944401-56-3
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$32.00/250mg
1370351-45-3
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1312445-63-8
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