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ChemicalBook CAS DataBase List Noopept
157115-85-0

Noopept synthesis

2synthesis methods
Noopept (ethyl ester of N-phenylacetyl-L-prolylglycine) was designed as a drug at State Zakusov Institute of Pharmacology. The synthesis of the drug is based on the original hypothesis of peptide design, according to which structures similar to known psychotropic agents are reproduced using appropriate amino acids. The non-peptide prototype of Noopept is the nootropic drug Piracetam.
Synthesis of Noopept
1. Perform the carboxylation of N-phenylacetyl-L-proline and ethyl glycine in the presence of isobutyl chloroformate.
2. Add slowly isobutyl chloroformate (1.17 g, 8.6 mmol) to a solution of N-phenylacetyl-L-proline (2.0 g, 8.6 mmol) dissolved in a mixed solvent of THF and dichloromethane (1:1; THF/dichloromethane (v/v)).3.Stir the mixture for 4 h at 0 ～5 °C
Molecular Mechanism Underlying the Action of Substituted Pro-Gly Dipeptide Noopept
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: N-methylmorpholine / CHCl3 / 0.03 h / -10 °C
2: N-methylmorpholine / CHCl3; dimethylformamide / 1.5 h / -5 - 20 °C

References:

Gudasheva;Voronina;Ostrovskaya;Rozantsev;Vasilevich;Trofimov;Kravchenko;Skoldinov;Seredenin [European Journal of Medicinal Chemistry,1996,vol. 31,# 2,p. 151 - 157]

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