N-Ethyl-N-hydroxyethylaniline synthesis
- Product Name:N-Ethyl-N-hydroxyethylaniline
- CAS Number:92-50-2
- Molecular formula:C10H15NO
- Molecular Weight:165.23
75-21-8
103-69-5
92-50-2
1. The autoclave was purged with nitrogen and protected by nitrogen with 24.2 kg (200 mol) of N-ethylaniline, 8.9 kg (202 mol) of ethylene oxide, and 242 g (1.9 mol) of taurine. 2. The autoclave was closed, making sure that the lid was screwed on tightly. 3. The heating system was turned on, and the temperature was ramped up to 102°C at a rate of 1°C/min before stopping the heating, and the temperature of the reaction will naturally rise to 133°C. 4. Maintain the reaction at 133°C for 4 h. 5. Upon completion of the reaction, the reaction mixture was cooled to 40°C. 6. Open the autoclave and collect the product to give 32.8 kg of N-ethyl-N-hydroxyethylaniline in 99.4% yield.
Yield:92-50-2 99.4%
Reaction Conditions:
with Tau at 102 - 133; for 4 h;Autoclave;Inert atmosphere;Industrial scale;Temperature;
Steps:
5 Example 5
The autoclave was purged with nitrogen and under nitrogen protection, 24.2 kg (200 mol) of N-ethylaniline, 8.9 kg (202 mol) of ethylene oxide, 242 g (1.9 mol) of taurine were added, and the autoclave was closed. Cap, and tighten, open the heating, heating to 102 °C at a heating rate of 1 °C / min, stop heating, the reaction temperature rose to 133 °C reaction 4. Oh, after the reaction is completed, cooled to 40 °C, discharge, 32.8 kg of N-ethyl-N-hydroxyethylaniline was obtained in a yield of 99.4%.
References:
CN108117492,2018,A Location in patent:Paragraph 0050; 0052; 0054; 0056; 0057; 0058
103-69-5
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$13.00/100g
92-50-2
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$10.00/5g