N-(2-fluoroethyl)aniline synthesis
- Product Name:N-(2-fluoroethyl)aniline
- CAS Number:459-40-5
- Molecular formula:C8H10FN
- Molecular Weight:139.17
Yield:459-40-5 79%
Reaction Conditions:
with bis[dichloro(pentamethylcyclopentadienyl)iridium(III)];sodium hydrogencarbonate in tert-Amyl alcohol at 100; for 24 h;Inert atmosphere;Solvent;Reagent/catalyst;
Steps:
4 Example 4
Under the protection of nitrogen, 20.006 mmol of [Cp * IrCl2], 0.3 mmol of aniline,0.33 mmol of fluoroethanol, 0.006 mmol of sodium bicarbonateAnd tert-amyl alcohol 0.5 mL, heated to 100 ° C and reacted for 24 h. After the reaction is over, drop toAt room temperature, add a small amount of water, 15mL ethyl acetate extraction three times, the organic phase, followed by saturated brine washing, anhydrous magnesium sulfateDried, and the solvent was distilled off under reduced pressure. The yield of the secondary amine was 79% by column chromatography.
References:
CN106748802,2017,A Location in patent:Paragraph 0019; 0020; 0021; 0022; 0023; 0024; 0025-0030
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