METHYL 7-BROMO-1-BENZOTHIOPHENE-2-CARBOXYLATE synthesis
- Product Name:METHYL 7-BROMO-1-BENZOTHIOPHENE-2-CARBOXYLATE
- CAS Number:550998-53-3
- Molecular formula:C10H7BrO2S
- Molecular Weight:271.13
149947-15-9
2365-48-2
550998-53-3
GENERAL METHOD: Under stirring conditions, 3-bromo-2-fluorobenzaldehyde (9.90 mmol) was dissolved in DMF (20 mL) and methyl mercaptoacetate (10.9 mmol) and potassium carbonate (39.6 mmol) were added sequentially. The reaction mixture was stirred continuously at 60 °C for 15 hours. After completion of the reaction, the DMF solvent was removed by distillation under reduced pressure. Water (50 mL) was added to the residue, which was subsequently extracted with ethyl acetate (2 x 40 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to remove the solvent to afford the target product, methyl 7-bromobenzo[b]thiophene-2-carboxylate.
1072-85-1
460 suppliers
$5.00/10g
550998-53-3
56 suppliers
$32.00/100mg
Yield:-
Steps:
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C
1.2: 1.17 h / -78 - 20 °C
2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C
2.2: 1.25 h / 0 - 20 °C
References:
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY;LEE, BYUNG HO;YI, KYU YANG;OH, KWANG SEOK;IM, CHAE JO;KIM, NAK JEONG;SO, JEE HEE;LEE, JEONG HYUN;SEO, HO WON KR2015/117318, 2015, A
149947-15-9
167 suppliers
$6.00/1g
2365-48-2
374 suppliers
$15.00/25g
550998-53-3
56 suppliers
$32.00/100mg
149947-15-9
167 suppliers
$6.00/1g
2365-48-2
374 suppliers
$15.00/25g
![Benzo[b]thiophene-2-carboxylic acid, 7-bromo-](/CAS/GIF/19075-59-3.gif)
19075-59-3
81 suppliers
$45.00/100mg
550998-53-3
56 suppliers
$32.00/100mg