午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List methyl 3-(benzyloxy)cyclobutanecarboxylate
4934-98-9

methyl 3-(benzyloxy)cyclobutanecarboxylate synthesis

8synthesis methods
-

Yield: 94%

Reaction Conditions:

with thionyl chloride at 0 - 75; for 16 h;

Steps:

1 Step 1
To a solution of 3-benzyloxycyclobutanecarboxylic acid (10 g, 48.49 mmol, 1 eq) in methanol (100 mL) was added thionyl chloride (11.54 g, 96.98 mmol, 7.03 mL, 2 eq) dropwise at 0 °C, then heated to 75 °C and stirred for 16 h. The reaction mixture was concentrated to give a residue which was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 20/1 to 5/1). Methyl 3-benzyloxycyclobutanecarboxylate (10.13 g, 45.99 mmol, 94% yield) was obtained as a colorless oil.

References:

ARVINAS OPERATIONS, INC. WO2021/11913, 2021, A1 Location in patent:Paragraph 1341; 1342