M-CRESOL-D3 (METHYL-D3) synthesis
- Product Name:M-CRESOL-D3 (METHYL-D3)
- CAS Number:25026-32-8
- Molecular formula:C7H5D3O
- Molecular Weight:111.16
20369-34-0
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25026-32-8
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Yield:25026-32-8 75%
Reaction Conditions:
with boron tribromide in dichloromethane at -60 - 0;
Steps:
3.2 Step 2 3-(2H3)methylphenol as brown oil:
To a solution of 1-methoxy-3-(2H3)methylbenzene (9 g, 71.89 mmol, 1.00 equiv) in dichloromethane (10 mL) was added BBr3 (144 mL, 2.00 equiv) at -60 °C. The resulting solution was stirred for 2 h at 0 °C. The reaction was then quenched by the addition of water/ice. The resulting solution was extracted with dichloromethane (3 x 50 mL). The organic layers were treated with sodium hydroxide solution (10%). Then the aqueous layers were acidified with hydrogen chloride (1 M), extracted with dichloromethane (3 x 50 mL), dried over anhydrous sodium sulfate and concentrated under vacuum to afford 6 g (75%) of 3-(2H3)methylphenol as brown oil.
References:
WO2016/133989,2016,A1 Location in patent:Paragraph 00180
2398-37-0
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1124-18-1
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21175-64-4
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25026-32-8
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108561-00-8
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70837-27-3
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