Ethanone, 1-(1H-pyrrolo[3,2-b]pyridin-5-yl)- synthesis
- Product Name:Ethanone, 1-(1H-pyrrolo[3,2-b]pyridin-5-yl)-
- CAS Number:1445856-03-0
- Molecular formula:C9H8N2O
- Molecular Weight:160.17
![5-Chloro-pyrrolo[3,2-b]pyridine-1-carboxylic acid tert-butyl ester](/CAS/20180527/GIF/1207625-34-0.gif)
1207625-34-0
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Yield:1445856-03-0 64%
Reaction Conditions:
Stage #1: tert-butyl 5-chloro-1H-pyrrolo[3,2-b]pyridine-1-carboxylate;tributyl(1-ethoxyvinyl)stannanewith tetrakis(triphenylphosphine) palladium(0) in N,N-dimethyl-formamide at 100;Sealed tube;Stille Cross Coupling;
Stage #2: with hydrogenchloride in tetrahydrofuran at 20;
References:
Lee, Wendy;Crawford, James J.;Aliagas, Ignacio;Murray, Lesley J.;Tay, Suzanne;Wang, Weiru;Heise, Christopher E.;Hoeflich, Klaus P.;La, Hank;Mathieu, Simon;Mintzer, Robert;Ramaswamy, Sreemathy;Rouge, Lionel;Rudolph, Joachim [Bioorganic and Medicinal Chemistry Letters,2016,vol. 26,# 15,p. 3518 - 3524]