Dimethyl malonate synthesis
- Product Name:Dimethyl malonate
- CAS Number:108-59-8
- Molecular formula:C5H8O4
- Molecular Weight:132.11
16695-14-0
119 suppliers
$9.00/1g
108-59-8
624 suppliers
$5.00/25g
Yield:108-59-8 95%
Steps:
18 Esterification of malonic acid monomethyl ester (acidic condition)
EXAMPLE 18 Esterification of malonic acid monomethyl ester (acidic condition) This example relates to a synthesis of methyl malonate (formula (IX)) under an acidic condition. Malonic acid monomethyl ester (0.5 g) obtained from Example 16 was added to acid and alcohol (conc. hydrogen chloride 0.1 ml, methanol 15 ml) and allowed to react together for 12 hours at 50° C. under argon to produce methyl malonate. 1H-NMR and gas chromatography analysis of the resulting product showed that the conversion rate and yield were 95% or more, respectively.
References:
US2002/35290,2002,A1
868-26-8
106 suppliers
$38.00/5g
108-59-8
624 suppliers
$5.00/25g
67-56-1
783 suppliers
$9.00/25ml
141-82-2
775 suppliers
$5.00/25g
16695-14-0
119 suppliers
$9.00/1g
108-59-8
624 suppliers
$5.00/25g
96-34-4
359 suppliers
$10.00/25g
108-59-8
624 suppliers
$5.00/25g