ChemicalBook CAS DataBase List DIMETHYL 5-BROMOISOPHTHALATE

DIMETHYL 5-BROMOISOPHTHALATE synthesis

9synthesis methods

Product Name:DIMETHYL 5-BROMOISOPHTHALATE
CAS Number:51760-21-5
Molecular formula:C10H9BrO4
Molecular Weight:273.08

23351-91-9

51760-21-5

[Preparation of dimethyl 5-bromoisophthalate from 5-bromoisophthalic acid] To a 500 mL three-necked flask equipped with a mechanical stirrer and a Dimroth condenser, 110 g (0.45 mol) of 5-bromoisophthalic acid, 500 mL of anhydrous methanol, and 10 g of concentrated sulfuric acid were added sequentially. The reaction mixture was heated under reflux conditions with stirring for 6 hours. Upon completion of the reaction, the mixture was left to cool to room temperature, followed by slow dropwise addition to 1 L of distilled water. The mixture was centrifuged with 5 wt% aqueous sodium bicarbonate solution to pH 7-8. The precipitated white precipitate was collected by filtration and washed with 2 L of distilled water in two portions. The resulting white solid was placed in a vacuum drying oven and dried under reduced pressure at 50 °C for 48 h to give 109 g (0.4 mol) of dimethyl 5-bromoisophthalate in 89% yield.

23351-91-9 Synthesis

23351-91-9
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51760-21-5
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$6.00/1g

Yield:51760-21-5 89%

Reaction Conditions:

with sulfuric acid;sodium hydrogencarbonate in methanol

Steps:

3 [Preparation of dimethyl 5-bromoisophthalate from 5-bromoisophthalic acid]
[Preparation of dimethyl 5-bromoisophthalate from 5-bromoisophthalic acid] Into a 500 ml flask equipped with a stirrer and a Dimroth condenser, 110 g of 5-bromoisophthalic acid obtained above, 500 ml of methanol and 10 g of a concentrated sulfuric acid were placed and the resultant mixture was heated under the refluxing condition for 6 hours. After the reaction mixture was cooled by being left standing, the cooled mixture was added dropwise to 1 liter of distilled water and the obtained mixture was neutralized with a 5% by weight aqueous solution of sodium hydrogencarbonate. The formed precipitates were separated by filtration and washed twice with 2 liters of distilled water. The obtained white solid substance was dried at 50?C under a reduced pressure for 2 days and 109 g (0.4 moles) of dimethyl 5-bromoisophthalate was obtained (the yield: 89%).

References:

SUMITOMO BAKELITE CO., LTD. EP1346975, 2003, A1

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99-27-4 Synthesis