Cetirizine Descarboxymethyl R-Isomer synthesis
- Product Name:Cetirizine Descarboxymethyl R-Isomer
- CAS Number:705289-61-8
- Molecular formula:C19H23ClN2O
- Molecular Weight:330.85
![4-[(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINEETHANOL DIHYDROCHLORIDE](/CAS/GIF/109806-71-5.gif)
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Yield:99 % ee
Reaction Conditions:
at 25;Resolution of racemate;
Steps:
1.1.3 1.3 Preparation of compound 1b (compound of formula I in free form wherein n=2. Y=OH, (R)-enantiomer):
The chromatographic separation of the enantiomers of compound la such as obtained in 1.2 is performed using 8 columns of 4.8 x 11.3 cm for 1 kg of chiral stationary phase CHIRALPAK AD (DAICEL) with methanol as the eluent. The chromatographic parameters are: K'1 (capacity factor of the R-enantiomer) = 0. 525 k'2 (capacity factor of the S-enantiomer) = 1. 111 Alpha (selectivity factor) = 2. 118 Resolution = 2. 164 Temperature = 23°C PURITY OF (R) -ENANTIOMER IS 99.5 %; EE = 99 %
References:
WO2004/65360,2004,A2 Location in patent:Page 9
107-07-3
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![(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine](/CAS/GIF/300543-56-0.gif)
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