alpha-hydroxypyridine-3-acetic acid synthesis
- Product Name:alpha-hydroxypyridine-3-acetic acid
- CAS Number:49769-60-0
- Molecular formula:C7H7NO3
- Molecular Weight:153.1354
155705-86-5
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Yield:49769-60-0 100%
Reaction Conditions:
with lithium hydroxide monohydrate;lithium hydroxide monohydrate in tetrahydrofuran at 20; for 16 h;
Steps:
78.3 Step 3:
A solution of methyl 2-hydroxy-2-(pyridin-3-yl)acetate (219 mg, 1.31 mmol) and lithium hydroxide (31.37 mg, 1.31 mmol) in water (0.5 mL) and tetrahydrofuran (0.5 mL) , stirred at room temperature for 1 hour, and then spin-dried to obtain the crude product 2-hydroxy-2-(3-pyridyl)acetic acid (200 mg, yield: 100%).
References:
WO2022/184152,2022,A1 Location in patent:Page/Page column 108-109
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17604-74-9
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