tert-butyl 4-(2-hydroxyethyl)-3-oxopiperazine-1-carboxylate synthesis
- Product Name:tert-butyl 4-(2-hydroxyethyl)-3-oxopiperazine-1-carboxylate
- CAS Number:910573-06-7
- Molecular formula:C11H20N2O4
- Molecular Weight:244.29
![1-Piperazinecarboxylic acid, 4-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-3-oxo-, 1,1-dimethylethyl ester](/CAS/20210305/GIF/786683-69-0.gif)
786683-69-0
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910573-06-7
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$307.00/100mg
Yield:910573-06-7 998 mg
Reaction Conditions:
with tetrabutyl ammonium fluoride in acetonitrile at 40;
Steps:
109.1 Step 1: Synthesis of tert-butyl 4-(2-hydroxyethyl)-3-oxopiperazine-1-carboxylate
At room temperature, compounds 59-2 (1.50g, 4.18mmol) and tetrabutylammonium fluoride (3.50g, 20.9mmol) were sequentially added to acetonitrile (20.0mL) and reacted at 40 °C for 15h. TLC monitors reaction endpoints. The reaction solution was concentrated under reduced pressure, the residue was diluted with water (100mL), dichloromethane (50ml x 3) was extracted, the organic phase was combined, dried by anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure. The crude product was purified by rapid silica gel column chromatography (dichloromethane: methanol=99:1~20:1) to obtain the title product (998mg, colorless oil).
References:
WO2023/16521,2023,A1 Location in patent:Page/Page column 124
76003-29-7
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910573-06-7
23 suppliers
$307.00/100mg