9-[1,1'-Biphenyl-4-yl]-3-bromo-9H-carbazole synthesis
- Product Name:9-[1,1'-Biphenyl-4-yl]-3-bromo-9H-carbazole
- CAS Number:894791-46-9
- Molecular formula:C24H16BrN
- Molecular Weight:398.29
Yield:894791-46-9 95%
Reaction Conditions:
with potassium carbonate;copper(l) chloride in acetonitrile at 0; for 4 h;Schlenk technique;
Steps:
3; 16
Add 0.2mmol (44mg) of biphenyl-4-hydrazine substrate, 0.2mmol (50mg) of 3-bromocarbazole, 1mg (5mol%) of cuprous chloride, 55mg (2eq.) of potassium carbonate to a 50mL Schlenk tube, Acetonitrile 2mL, magnetron was added, and the reaction was stirred at 0°C for 4h. After the reaction is over, add 50 mL of saturated brine, extract three times with 3*50 mL of dichloromethane, add anhydrous sodium sulfate to dry for 30 minutes, and then use a rotary evaporator to remove the low-boiling solvent. The reaction liquid was subjected to column evaporation after rotary evaporation to obtain the target product with a yield of 95%.
References:
CN112010798,2020,A Location in patent:Paragraph 0053-0056; 0099
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