5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine synthesis
- Product Name:5-(4-methylpiperazin-1-yl)-1H-1,2,4-triazol-3-amine
- CAS Number:89292-91-1
- Molecular formula:C7H14N6
- Molecular Weight:182.23
109-01-3
10191-60-3
89292-91-1
GENERAL METHOD: A mixed solution of N-cyanoimido-S,S-dimethyl dithiocarbonate (17.4 mmol), acetonitrile (10 mL) and N-methylpiperazine (17.4 mmol) was heated and refluxed for 2 hours. After the reaction was completed, it was cooled to room temperature, hydrazine monohydrate (25.6 mmol) was added, and heating and refluxing was continued for 5 hours. At the end of the reaction, the solvent was removed by evaporation under reduced pressure and the resulting crude product was purified by recrystallization using ethyl acetate. Operating according to General Method B, the compound 3-amino-5-(4-methylpiperazinyl)-1H-1,2,4-triazole (11k) was obtained as a light yellow solid in 80% yield with a melting point of 103-104 °C. 1H NMR (200 MHz, DMSO-d6) δ: 10.95 (br s, 1H); 5.72 (br s, 2H); 3.16- 3.11 (m, 4H); 2.34-2.29 (m, 4H); 2.17 (s, 3H).
75565-11-6
4 suppliers
inquiry
74-93-1
145 suppliers
$454.02/5MG
89292-91-1
66 suppliers
$37.00/250mg
Yield:89292-91-1 88%
Reaction Conditions:
with hydrazine hydrate in ethanol;Heating;
References:
Reiter, Jozsef;Pongo, Laszlo;Somorai, Tamas;Dvortsak, Peter [Journal of Heterocyclic Chemistry,1986,vol. 23,p. 401 - 408]
109-01-3
675 suppliers
$5.00/5G
10191-60-3
219 suppliers
$6.00/5g
89292-91-1
66 suppliers
$37.00/250mg
109-01-3
675 suppliers
$5.00/5G
89292-91-1
66 suppliers
$37.00/250mg
75565-11-6
4 suppliers
inquiry
89292-91-1
66 suppliers
$37.00/250mg