7-FLUOROQUINAZOLINE-2,4(1H,3H)-DIONE synthesis
- Product Name:7-FLUOROQUINAZOLINE-2,4(1H,3H)-DIONE
- CAS Number:76088-98-7
- Molecular formula:C8H5FN2O2
- Molecular Weight:180.14
446-32-2
76088-98-7
General procedure for the synthesis of 7-fluoroquinazoline-2,4(1H,3H)-dione from 2-amino-4-fluorobenzoic acid: 2-amino-4-fluorobenzoic acid (5.00 g, 32.2 mmol) was dissolved in water (180 mL), glacial acetic acid (3 mL) was added, and the temperature was heated to 35 °C. At this temperature, a suspension of sodium cyanate (5.24 g, 80.6 mmol) in water (20 mL) was slowly added. The residual sodium cyanate was washed with three portions of water (10 mL each). After continuing to stir the reaction mixture for 30 min, sodium hydroxide (35 g, 880 mmol) was slowly added and a white precipitate was observed to be produced. Water (100 mL) was added to dilute, the reaction mixture was cooled to 0 °C and the pH was adjusted with concentrated hydrochloric acid to 4. The white solid was collected by filtration, washed with water and dried under vacuum to afford 7-fluoroquinazoline-2,4(1H,3H)-dione 4.1 g in 71% yield.
124-38-9
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$214.00/14L
80517-22-2
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76088-98-7
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$45.00/50mg
Yield:76088-98-7 93%
Reaction Conditions:
with potassium carbonate;1,3-bis[(2,6-diisopropyl)phenyl]imidazolinium chloride in dimethyl sulfoxide at 120; under 750.075 Torr; for 8 h;High pressure;Autoclave;
References:
Xiao, Yunqing;Kong, Xianqiang;Xu, Zhicheng;Cao, Changsheng;Pang, Guangsheng;Shi, Yanhui [RSC Advances,2015,vol. 5,# 7,p. 5032 - 5037]
446-32-2
448 suppliers
$6.00/5g
76088-98-7
82 suppliers
$45.00/50mg
590-28-3
257 suppliers
$10.00/5g
446-32-2
448 suppliers
$6.00/5g
76088-98-7
82 suppliers
$45.00/50mg
